H. et al. Inhibition of the integrated stress response by viral proteins that block p-eIF2–eIF2B association. Nat. Microbiol. 5, 1361–1373 (2020). Article CAS PubMed Google Scholar Cameron, C. M., Barrett, J. W., Mann, M., Lucas, A. & McFadden, G. Myxoma virus M128L is ...
Ubiquitin is a 76-amino acid protein, and as such bears many potential sites for additional post-translational modifications. The key features of ubiquitin are its seven Lys residues, all of which can be ubiquitinated, to give rise to isopeptide-linked ubiquitin chains. An eighth chain type, Me...
CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules...
dissolved CO2partially reacts with water to form H2CO3, which dissociates into HCO3−and H+. The balance between H2CO3and HCO3−levels underlies the most important mechanism of maintaining blood pH; H2CO3and HCO3−are able to neutralize excess bases and acids, respectively...
(fru) to block production of a male-specific form in ISCs [65]. In contrast, Sxl expression in ISCs is not observed in males, and the male-specific isoform is present due to dsx and fru dysregulation in ISCs [65]. This study also suggested that the intrinsic sexual identity of ISCs ...
For synchronization, cells transfected with miR-NC or miR-188 were treated with 2 mM hydroxyurea (Sigma-Aldrich, H8627) for 16 h to block cell at G1 phase. The synchronized cells were released by washing the cells 3 times with pre-warmed PBS. At 6 h after release, the cells were fixe...
To ensure representativeness and homogeneity, the whole dots were observed in tissue microarray, and 5 fields of immune cell highly infiltrated tumor area were selected in the FFPE block slide. All the evaluation was performed by the same pathologist blinded to patient characteristics. Tumor ...
Compared to proteins, glycans, and lipids, much less is known about RNAs on the cell surface. We develop a series of technologies to test for any nuclear-encoded RNAs that are stably attached to the cell surface and exposed to the extracellular space, he
Abdel-Azim, H., Elshoury, A., Mahadeo, K. M., Parkman, R. & Kapoor, N. Humoral immune reconstitution kinetics after allogeneic hematopoietic stem cell transplantation in children: a maturation block of IgM memory B cells may lead to impaired antibody immune reconstitution. Biol. Blood Marrow...
213 Of note, lactoferrin, a component of neutrophil granules, can block netotic cell death and inflammation both in vitro and in vivo.214 In addition to the key role of GSDMD in pyroptosis, GSDMD is also involved in the induction of NETosis to digest the pathogen,112,113 indicating a ...