OA12.02 Randomized Phase II Study of CDDP+S-1 vs CDDP+PEM Combined with Thoracic RT for Locally Advanced Non-Sq NSCLC: SPECTRA Studydoi:10.1016/j.jtho.2019.08.472T. SetoS. NihoT. YoshidaT. AkimotoY. OheJournal of Thoracic Oncology
MO2-14-1Randomized phase II study of CDDP+S-1 vs CDDP+PEM combined with thoracic RT for locally advanced non-squamous NSCLCBackground We previously reported that toxicities were tolerable and manageable in both arms; however, febrile neutropenia was more frequently observed in the CDDP+S-1 arm...
应用流式细胞术检测耐药细胞的周期变化,Transwell迁移实验检测其迁移能力的改变,实时荧光定量聚合酶链反应(RT-qPCR)检测细胞中多药耐药相关基因的变化.结果 成功获得对CDDP耐药的细胞株JF305/CDDP和对GEM耐药的细胞株PANC-1/GEM.JF305/CDDP和PANC-1/GEM细胞株的耐药指数分别为15.3和27.31,并存在交叉耐药.与亲代细胞...
The mRNA and protein levels of HIF-1α, multidrug resistance-1 (MDR1), and multidrug resistance-associated protein (MRP) were determined by reverse transcription polymerase chain reaction (RT-PCR) and immunocytochemistry. Cell viability following treatment with cisplatin was determined by MTT assay. ...
Preradiation chemotherapy using ACNU-CDDP was administered as an initial adjuvant therapy for 87 (57.6%) patients (ACNU-CDDP group), radiation therapy was performed in 31 (20.5%) patients (RT group) and the remaining 33 (21.9%) patients were treated with other regimens or refused to...
Wadler S, Beitler JJ, Rubin JS, Haynes H, Mcgill F, Rozenblit A, Goldberg G, Cohen C, Speyer J and Runowicz C (1993) Pilot trial of cisplatin, radiation, and WR 2721 in carcinoma of the uterine cervix: a New York gynecologic oncology group study. J Clin Oncol 11: 1511-1516...
Radiotherapy (RT) combined with cisdiammine-dichloroplatinum (cDDP) as radioenhancer in a dose escalating way, in non small cell lung cancer (NSCLC)doi:10.1016/S0169-5002(86)80564-5NoneELSEVIERLung Cancer
In conclusion, treatment with concomitant CDDP, NVB, and chest RT is feasible. A NVB dose of 15 mg/m2 given 2 of every 3 weeks is tolerable and a day 1, day 2 NVB schedule is under analysis. Esophagitis is dose limiting, and pts may require nutritional support. The 66% reduction ...