随后,他们利用scRNA-seq分析了经CD8-mIL2治疗后的肿瘤浸润淋巴细胞,表达细胞因子(Ifng、Tnfa)和效应分子(Fasl、Gzma)的效应细胞群体被显著诱导,提示疗效与肿瘤浸润CD8+T细胞的扩增和活性增强有关。 最后,该团队进一步给食蟹猴静脉注射AB2...
这表明CD4-Runx3也需要Tgf-b信号促使其Trm特征的形成。 搞到这里还有一个问题没解决,开始我们说到CD8Trm不会乱跑,而CD4Trm到处乱跑发挥巡逻的作用,那么Runx3会改变这种特征吗,果不其然,Runx3不仅仅会驱动其向皮肤募集,并且也会让它安...
路径分析表明,在这些簇中,KRAS信号、MYC靶点和mTORC1信号被抑制,支持KRASG12D的有效靶向。此外,MRTX1133处理的簇还抑制了几条免疫调节途径,包括通过NFkB的TNFA信号、炎症反应和同种异体移植。对KPC689细胞死亡受体的进一步分析表明,经MRTX1133处理后,Fas的mRNA表达增加。 此外,MRTX1133处理的KPC689原位肿瘤显示CD8+细...
92 ENDOTHELIAL CELL CROSS-PRESENTATION INITIATES TNFA-DEPENDENT CD8 T CELL IMMUNITY AGAINST VIRUS-INFECTED HEPATOCYTESCD8HepatitisLSECViral infections in the liver are generally considered to be cleared in an MHC class I restricted killing of hepatocytes by CD8+ T cells. We believe that direct ...
Concordantly, the CUL5 KO group had a significantly higher number of tumor-infiltrating transferred T cells that were still capable of producing IFNg and/or TNFa upon in vitro re-stimulation than the NC group (Fig. 2e, Supplementary Fig. 3d, e). Other tumor-infiltrated immune cell types, ...
a. Enrichment plots of selected upregulated pathways (IL6 JAK STAT3 signaling, Inflammatory response, TNFA signaling via NFKB and Interferon Gamma Response). b. Enrichment plots of selected downregulated pathways (Bile acid metabolism and Fatty Acid Metabolism). (c) Experiment 4. c. Survival ...
Gene set enrichment analysis (GSEA) using the Hallmark pathways identified that signaling pathways like PI3K-AKT-MTOR signaling and TNFA signaling via NF-κβwere enriched in post-transplanted CD8 T cell from WT mice compared to cells from TCF-1 cKO mice (Supp. Fig. 7A-B). GSEA analysis us...
并且,如图I-K所示,与Osr2fl/fl CAR-T细胞相比,Osr2缺失的CAR-T细胞具有更高的存在频率,这与转移后15天肿瘤微环境(TME)中Ki-67+细胞水平升高、凋亡细胞减少密切相关,同时表现为IFNg+ TNFa+细胞比例增加,以及PD-1、TIM-3和LAG-3表达降低。上述结果表明,Osr2的缺失能够通过减轻TME中的T细胞耗竭,从而提高CAR-...
Tumor-necrosis-factor-alpha-induced protein 3 (TNFAIP3), or A20, is a ubiquitin-modifying protein and negative regulator of canonical nuclear factor κB (NF-κB) signaling. Several single-nucleotide polymorphisms in TNFAIP3 are associated with autoimmune diseases, suggesting a role in tissue inflamma...
NF-kB activation results in rapid inactivation of JNK in TNFa-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-kB. Oncogene 20, 4365–72, https://doi.org/10.1038/sj.onc.1204570 (2001). Article CAS PubMed Google Scholar De Smaele, E. et al. Induction of ...