TNF-α and CD8+ T cells me- diate the beneficial effects of nitric oxide synthase-2 deficiency in pulmonary paracoccidioidomycosis. PLoS Negl Trop Dis 2013; 78: e2325.Bernardino S, Pina A, Felonato M, Costa TA, Frank de Araujo E, Feriotti C, ...
在B16小鼠黑色素瘤模型中,癌细胞分泌的TNF 促进了肿瘤对骨髓细胞的浸润以及内皮标志物的表达,从而促进肿瘤血管化和进展[17]。而体内研究表明使用靶向抗体阻断 TNF/TNFR1 信号通路能够增加微环境中黑色素瘤特异性 CD8+ T 细胞的比例并延缓肿瘤生长[18]。 另外,研究发现肿瘤相关TNF还可以影响癌细胞的分化。在接受 AC...
Cells expressing CD4 secrete TNF-alpha while CD8 cells secrete little or no TNF-alpha. The synthesis of TNF-alpha is induced by many different stimuli including interferons, IL2 , GM-CSF. Description : Recombinant Human Tumor Necrosis Factor-alpha produced in E.Coli is a single, non-...
(B) Percentage of CD8 + T cells with double-positive intracellular staining (TNF-alpha and IFN-gamma) after incubation with each of the 43 predicted HLA-I neoepitopes, and HLA-I predicted binding affinity wild-type to mutant ratio ( Table S5 B). Mutation in gene FLG2 E1608K (P12) was...
Here, we used a novel immunization strategy to generate memory CD8 T cells in the wild type and gene-deficient BALB/c mouse model of sporozoite infection to examine the role of these T cell effector molecules in resistance to the liver stage infection. In contrast to previous work examining ...
体外研究Pomalidomide抑制脂多糖(LPS)刺激的TNF-alpha释放,作用于人类 PBMC和人类全部血液时,IC50分别为13nM和25nM。Pomalidomide抑制IL-2刺激的T调节细胞,IC50为~1μM。6.4nM-10μM Pomalidomide处理人类外周血T细胞,提高IL-2产量,作用于CD4+子集比作用于CD8+子集有效。Pomalidomide比CC-5013显著促进IL-2、IL-5和...
体外研究Pomalidomide抑制脂多糖(LPS)刺激的TNF-alpha释放,作用于人类 PBMC和人类全部血液时,IC50分别为13nM和25nM。Pomalidomide抑制IL-2刺激的T调节细胞,IC50为~1μM。6.4nM-10μM Pomalidomide处理人类外周血T细胞,提高IL-2产量,作用于CD4+子集比作用于CD8+子集有效。Pomalidomide比CC-5013显著促进IL-2、IL-5和...
目前,已知表达TNF-alpha的人类细胞有: B细胞,结肠柱状上皮细胞,NK细胞,CD3+CD56+肝自然T细胞,巨噬细胞,单核细胞,树突状细胞,CD4+ CD8+ T细胞, 肥大细胞,嗜中性粒细胞,角化细胞,血浆细胞以及脂肪细胞等。 维护中,请联系客服 维护中,请联系客服
Such a technique requires careful application of cell isolation techniques, and culturing the cells with multiple cytokine supplements to obtain the desired immune cell sub-sets (dendritic cells, CD4+and or CD8+T cells) and are not conducive to rapid through-put screening using multiple donor ...
inflammatory killing of normal melanocytes, but also induced a CD8(+) T-cell-dependent, antigen-specific response in mice that eradicated systemically establi... GA Daniels,L Sanchez-Perez,RM Diaz,... - 《Nature Biotechnology》 被引量: 228发表: 2004年 Elimination of CD4(+) T cells enhances...