定义CD8+T细胞在特定组织环境中的代谢适应,有助于我们了解这些细胞如何在屏障部位防止病原体和肿瘤发生,以保持组织健康。2021年5月,Miguel Reina-Campos等人在《Nat Rev Immunol》杂志上发表了一篇题为《CD8+T cell metabolism in infection and cancer》的综...
定义CD8+T细胞在特定组织环境中的代谢适应,有助于我们了解这些细胞如何在屏障部位防止病原体和肿瘤发生,以保持组织健康。2021年5月,Miguel Reina-Campos等人在《Nat Rev Immunol》杂志上发表了一篇题为《CD8+T cell metabolism in infection and cancer》的综述,揭示了代谢网络如何执行特定的CD8+T细胞程序,并讨论了代...
Metabolic programs tailor T cell immunity in viral infection, cancer, and aging. Cell Metab. 34, 378–395 (2022). Article PubMed Google Scholar Warburg, O., Gawehn, K. & Geissler, A. W. Metabolism of leukocytes. Z. Naturforsch. B 13B, 515–516 (1958). Article CAS PubMed Google ...
1、细胞毒性t淋巴细胞(ctl细胞),通常称为cd8+t细胞,是一种抗原特异性t细胞,是适应性免疫系统的关键组成部分,监视机体并清除感染,尤其是在消除细胞内感染和恶性细胞中发挥关键作用,同时可提供长期保护性免疫(cd8+t cell metabolismin infectionand cancer.nat rev immunol.2021nov;21(11):718-738.)。cd8+t细胞在人...
and oxidation, regulate CD8+ T cells within tumors. We also assessed the impact of different lipids on CD8+ T-cell-mediated antitumor immunity, with a particular focus on how lipid metabolism affects mitochondrial function in tumor-infiltrating CD8+ T cells. Furthermore, as cancer is a systemic...
J. CD8 T cell exhaustion during chronic viral infection and cancer. Annu. Rev. Immunol. 37, 457–495 (2019). CAS PubMed Google Scholar Baumeister, S. H., Freeman, G. J., Dranoff, G. & Sharpe, A. H. Coinhibitory pathways in immunotherapy for cancer. Annu. Rev. Immunol. 34, ...
CD8 + T cell metabolism in infection and cancer. Nat Rev Immunol. 2021;21:718–38. Article CAS PubMed PubMed Central Google Scholar Igarashi K, Ochiai K, Itoh-Nakadai A, Muto A. Orchestration of plasma cell differentiation by Bach2 and its gene regulatory network. Immunol Rev. 2014...
CD8 T cells, which have a crucial role in immunity to infection and cancer, are maintained in constant numbers, but on antigen stimulation undergo a developmental program characterized by distinct phases encompassing the expansion and then contraction of antigen-specific effector (T(E)) populations,...
CD8+ T cell Resistance Immune checkpoint inhibitor (ICI) Programmed death-1 receptor (PD-1) Programmed death-ligand 1 (PD-L1) Exhaustion 1. Introduction Immune checkpoint inhibitor (ICI) resistance is a critical challenge in cancer immunotherapy. Resistance is a multi-factorial event, and generally...
in the fight against the constantly changing and evolving cancers, the formation and function of CD8+T cells can be challenged by tumors that might train a group of accomplices to resist the T cell killing. As cancer therapy stepped into the era of immunotherapy, understanding the physiological...