CD8 T cells in the cancer-immunity cycle. CD8+T细胞是癌症免疫的末端效应物。大多数形式的有效癌症免疫疗法涉及CD8+T细胞效应功能。在这里,我们回顾了目前对癌症中T细胞功能的理解,重点关注关键的CD8+T细胞亚型和状态。我们通过包含经典三信号模型和第四个信...
[1]Elewaut A, Estivill G, Bayerl F, et al. Cancer cells impair monocyte-mediated T cell stimulation to evade immunity[J]. Nature, 2024. [2]Campana S, De Pasquale C, Carrega P, et al. Cross-dressing: an alt...
除了CD8+T活化所需要的四个信号,关于CD8+T的分化的详情欢迎大家扫码免费领取! 原文链接 Giles JR, Globig AM, Kaech SM, Wherry EJ. CD8+ T cells in the cancer-immunity cycle. Immunity. 2023 Oct 10;56(10):2231-2253. doi: 10.1016/j.immuni.2023.09.005. PMID: 37820583. 关注福麦斯生物公众号,...
Although Tregs play a critical role in curbing autoreactive T cells, they also constrict productive antitumor immune responses through a variety of mechanisms and at various stages of the tumor-immunity cycle43,44. Using flow cytometry and bulk-RNA sequencing, we probe the immunological mechanism ...
Immunotherapy elicits a systemic antitumour immune response in peripheral circulating T cells. However, the T cell trafficking circuit between organs and their contributions to antitumour immunity remain largely unknown. Here we show in multiple mouse le
CD8 T cells natural killer cells cancer vaccines HLA-E Qa-1 NKG2A mouse tumor models immune checkpoints IFN-γ acquired resistance Introduction Checkpoint blockade therapy has shown impressive results in metastasized malignant disease, including melanoma, lung, colon, and bladder carcinoma (Topalian et...
The basics of cancer immunotherapy is to initiate and optimize the key procedures in the innate or acquired immune system, including but not limited to, surveillance, identification, and elimination of tumors [1]. The ultimate executors of acquired cellular immunity, i.e., CD8+T cells, are exc...
Cytotoxic T cells Introduction The basics of cancer immunotherapy is to initiate and optimize the key procedures in the innate or acquired immune system, including but not limited to, surveillance, identification, and elimination of tumors [1]. The ultimate executors of acquired cellular immunity, i...
While extensively profiled in the tumor microenvironment, recent studies in mice identified responses in lymph nodes (LNs) as essential; however, the role of LNs in human cancer patients remains unknown. We examined CD8+ T cells in human head and neck squamous cell carcinomas, regional LNs, ...
A fundamental challenge for cancer vaccines is to generate long-lived functional T cells that are specific for tumour antigens. Here we find that mRNA–lipoplex vaccines against somatic mutation-derived neoantigens may solve this challenge in pancreatic