除了CD8+T活化所需要的四个信号,关于CD8+T的分化的详情欢迎大家扫码免费领取! 原文链接 Giles JR, Globig AM, Kaech SM, Wherry EJ. CD8+ T cells in the cancer-immunity cycle. Immunity. 2023 Oct 10;56(10):2231-2253. doi: 10.1016/j.immuni.2023.09.005. PMID: 37820583. 关注福麦斯生物公众号,...
[1]Elewaut A, Estivill G, Bayerl F, et al. Cancer cells impair monocyte-mediated T cell stimulation to evade immunity[J]. Nature, 2024. [2]Campana S, De Pasquale C, Carrega P, et al. Cross-dressing: an alt...
The basics of cancer immunotherapy is to initiate and optimize the key procedures in the innate or acquired immune system, including but not limited to, surveillance, identification, and elimination of tumors [1]. The ultimate executors of acquired cellular immunity, i.e., CD8+T cells, are exc...
Although Tregs play a critical role in curbing autoreactive T cells, they also constrict productive antitumor immune responses through a variety of mechanisms and at various stages of the tumor-immunity cycle43,44. Using flow cytometry and bulk-RNA sequencing, we probe the immunological mechanism ...
CD8 < sup>+ T cells in the cancer-immunity cycle.2023, 56(10):2231–2253. Khan AB, Carpenter B, Santos ESP, Pospori C, Khorshed R, Griffin J, Velica P, Zech M, Ghorashian S, Forrest C, et al. Redirection to the bone marrow improves T cell persistence and antitumor functi...
The functions of, and interactions between, the innate and adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of current successful cancer immunotherapies. Immune...
2024年8月15日,杜文静教授课题组在Molecular cell杂志发表了题为Malic Enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+T cells(苹果酸酶2维持CD8+T细胞的代谢稳态和抗肿瘤免疫能力)的研究论文。 在该研究工作中,研...
2024年8月15日,杜文静教授课题组在Molecular cell杂志发表了题为Malic Enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells(苹果酸酶2维持CD8+ T细胞的代谢稳态和抗肿瘤免疫能力) 的研究论文。 在该研究工作中,研究人员首先构建了苹果酸酶2(ME2) T细胞条件性基因敲除小鼠 (CD4-Cre;ME2...
2024年8月15日,杜文静教授课题组在Molecular cell杂志发表了题为Malic Enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+T cells(苹果酸酶2维持CD8+T细胞的代谢稳态和抗肿瘤免疫能力)的研究论文。 在该研究工作中,研究人员首先构建了苹果酸酶2(ME2) T细胞条件性基因敲除小鼠(CD4-Cre;ME2fl/fl...
2024年3月,中国科学技术大学朱书及潘文共同通讯在Immunity(IF 32.4)在线发表题为“Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions”的研究论文,该研究筛选了一个肠道微生物衍生代谢物库,并确定脱氧胆酸(DCA)是CD8+ T细胞效应功能的负...