1. L. M. McLane, M. S. Abdel-Hakeem, E. J. Wherry, CD8 T cell exhaustion during chronic viral infection and cancer. Annu. Rev. Immunol. 37, 457–495 (2019).2. D. L. Barber, E. J. Wherry, D. Masopust, B. Zhu, J. P. Allison, A. H. Sharpe, G. J. Freeman, R. Ahme...
2024年8月8日,Cell杂志背靠背在线发表美国匹兹堡大学医学院Dario A.A. Vignali研究团队题为LAG-3 and PD-1 synergize on CD8+T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity和Bl...
2.McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. CD8 T cell exhaustion during chronic viral infection and cancer.Annu. Rev. Immunol.37, 457–495 (2019). 3.Waugh, K. A. et al. Molecular profile of tumor-specific CD8+ T cell hypofunction in a transplantable murine cancer m...
15. Abdel-Hakeem, M.S., et al., Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation. Nat Immunol, 2021. 22(8): p. 1008-1019.16. Wherry, E.J., et al., Molecular signature of CD8+ T cell exhaustion during chronic viral ...
2 McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. Annual review of immunology 37, 457-495, doi:10.1146/annurev-immunol-041015-055318 (2019).3 Barber, D. L. et al. Restoring function in exhausted CD8 T cells ...
ExhaustionToleranceDuring chronic viral infections, responses by virus-specific CD8+ T cells become marginalized by the acquisition of functional defects and reduced cell numbers in a process defined as T cell exhaustion. Similarly, T cell tolerance to self-antigen is also characterized by impaired ...
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J. CD8 T cell exhaustion during chronic viral infection and cancer. Annu.Rev. Immunol. https://doi.org/10.1146/annurev-immunol-041015-055318 (2019). 56. Egelston, C. A. et al. Human breast tumor-infiltratingCD8+ T cells retain polyfunctionality despite PD-1 expression. Nat.Commun. https...
2. Barber, D.L., et al., Restoring function in exhausted CD8 T cells during chronic viral infection. Nature,2006. 439(7077): p. 682-7. 3. Doering, T.A., et al., Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory. Immunity...
Zhu B, Allison JP, Sharpe AH, Freeman GJ, Ahmed R. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006 Feb 9;439(7077):682-7. doi: 10.1038/nature04444. Epub 2005 Dec 28.3.CD8+ T Cell Exhaustion in Cancer. FrontImmunol. 2021; 12: 715234.