Exposure to stress did not change the expression of canonical markers of T cell activation including CD62L and CD44 or modified intracellular cytokine content, suggesting that they are not the main producers of circulating cytokines in response to stress. These results show that CD8(+) T cells ...
To determine whether CXCR5+ CD8+ T cells are directly responsible for axonal regenerative decline after sciatic nerve injury, WT or CXCR5-/- CD8+ T cells were isolated and adoptively transferred to the young and aged OT-I Rag-/- mice, which are B/T cell deficient, and mice were sacrifice...
Depending on cytokine and stromal cell signalling, they may also differentiate into T-helper and T-regulatory cells. MHC: major histocompatibility complex. Full size image T-cell activation: initial interactions CD8+ T cells interact with major histocompatibility complex class-1 (MHC-1) molecules6 ...
近日,来自德国慕尼黑工业大学的Percy A. Knolle团队在Nature杂志上发表了一篇题为A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection的文章,他们证明肝窦内皮细胞(LSEC)作为肝脏“免疫变阻器”,通过与HBV病毒特异...
CD8 + T-cell interaction with HCV replicon cells: Evidence for both cytokine- and cell-mediated antiviral activity The interaction between the host immune response and infected hepatocytes plays a central role in the pathogenesis of hepatitis C virus (HCV). The lack of ... C Liu,H Zhu,Z Tu...
1、A central pursuit in the field of memory T cell development has been to identify the population of antigen-specific effector CD8 T cells that has the potential to develop into long-lived memory cells. 记忆T细胞发育领域的一个核心追求是确定有可能发展成长期记忆细胞的抗原特异性效应器CD8T细胞的群...
, cytokine production, and T cell activation. Tranomic profiling and biochemical interrogation revealed arole for DHX37 in modulating NF-κB. These data demonstrate high-throughput invivo genetic screens for immunotherapy target discovery and establishes DHX37 as a functional regulator of CD8 T cells...
Most markers that define functional subsets of CD8+ T cells are regulated by activation, which complicates their use as differentiation markers. Although during acute infection overall similarities dominate between T cells specific for different viruses, their phenotypes seem to be distinct in the memor...
Cytokine-facilitated priming of CD8+T cell responses by DNA vaccination Immune responses elicited by plasmid DNA vaccination can be enhanced and modulated by codelivery of cytokine-encoding plasmids. We studied whether priming ... M Kwissa,A Kr?Ger,H Hauser,... - 《Journal of Molecular Medicine...
In conclusion, after intravenously administered CD3×CD19 bsAb only moderate toxicity was found, probably due to CD8 + T cell activation and cytokine release, without CD4 + T cell activation. 展开 关键词: Bispecific antibody Cytokines Phase I study Non-Hodgkin lymphoma T cell activation DOI: ...