To test if this IL-2R alpha is important for DC function, DC were isolated from the spleens of mutant mice with the IL-2R alpha gene disrupted and compared with normal DC for ability to stimulate proliferation of allogeneic CD4 and CD8 T cells in culture...doi...
However, cytokines that are produced by cells of the innate immune system also have a key role in CD8 + T-cell responses, by enhancing 'cross-presentation' and/or inducing CD8 + T-cell priming and differentiation. Here, we discuss how innate cytokine responses regulate CD8 + T-cell ...
However, cytokines that are produced by cells of the innate immune system also have a key role in CD8 + T-cell responses, by enhancing 'cross-presentation' and/or inducing CD8 + T-cell priming and differentiation. Here, we discuss how innate cytokine responses regulate CD8 + T-cell ...
IL-27 elicits a cytotoxic CD8+ T cell program to enforce tumour control IL-27 promotes tumour control by preventing dysfunction and enhancing cytotoxicity of tumour-specific CD8+ T cells. Béatrice Bréart Katherine Williams Nathaniel R. West Research05 Feb 2025 Nature P: 1-8 The oncolytic...
CD8+ T cells must be activated by cytokines released by Th1 lymphocytes. Explain. Adaptive Immunity: The adaptive immune system launches specific responses to pathogens that have invaded the body, and also remembers these pathogens to make future defenses against th...
A recent study has shown that IL-4 plays a critical role in vaccine induced protection against VL by enhancing IFN-γ production by CD8+ T cells [42]. 5. IL-4, IL-13 and STAT6 IL-4 and IL-13 are the signature cytokines associated with Th2-type immune responses and a...
immune system, and the differentiation of naive CD4+ T cells into distinct T-helper subsets is critical for normal immunoregulation and host defense. These... P Li,R Spolski,W Liao,... - 《Immunological Reviews》 被引量: 56发表: 2015年 Mouse CD8+ T cell subsets differentially generate IL...
A clear Th1 cytokine profile of CD4+ as well as of CD8+ T cells was demonstrated in BALF from sarcoidosis patients. This was most pronounced for CD8+ cells, which may therefore make an important contribution to the inflammatory process in the lungs in pulmonary sarcoidosis. 展开 ...
In addition to CD4+ T cells, IL-17 is produced by CD8+ cells, γδ T cells, invariant NKT cells, eosinophils, neutrophils, and activated monocytes (reviewed in [122]). Thus, IL-17 is produced by cells belonging to both the innate and adaptative immunity. Pro-inflammatory effects of ...
Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 1995; 270: 1811–5. ArticlePubMedGoogle Scholar ...