该研究以“The primordial differentiation of tumor specific memory CD8+T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes”为题于2022年10月27日正式刊登于国际生命科学顶级期刊Cell上(doi.org...
Here we developed a mouse model in which skin-specific expression of T cell antigens in the epidermis caused local infiltration of antigen-specific CD8 T cells with an effector gene-expression profile. In this setting, PD-1 enabled the maintenance of skin tolerance by preventing tissue-...
2024年8月8日,Cell杂志背靠背在线发表美国匹兹堡大学医学院Dario A.A. Vignali研究团队题为LAG-3 and PD-1 synergize on CD8+T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity和Bl...
厘清这些领域内的关键性分歧对深入理解恶性肿瘤情形下的PD-1 ICB作用机制具有重要意义。2022年10月7日，陆军军医大学全军免疫学研究所叶丽林团队与合作者中山大学中山医学院唐忠辉团队及南京大学鼓楼医院孙倍成团队在Cell杂志发表了文章The primordial differentiation of tumor specific memory CD8+ T cells as bona fide ...
为了证明这点，来自美国埃默里大学医学院的Kelsey B. Bennion团队在Science Translational Medicine杂志上发表了一篇题为 FcγRIIB expressed on CD8+ T cells limits responsiveness to PD-1 checkpoint inhibition in cancer 的文章，他们描述了FcγRIIBpos和FcγRIIBneg CD8+T细胞对是否含Fc片段的检查点抑制剂的...
P: 1-20 TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion Blockade of alternative T cell checkpoint molecules, such as Tim3, is a promising alternative to inhibition of PD-1-PD-L1 interaction in cancers. Here authors show that anti-Tim3 therapy is working...
Checkpoint blockade; T cell exhaustion; PD-1 blockade; CTLA-4 blockade; single-cell sequencing; combination checkpoint blockade; progenitor exhausted CD8+ T cells; clonotypic analysis; melanoma; immunotherapy Introduction Para_01 免疫检查点抑制剂,如抗PD-1疗法(αPD-1)和抗CTLA-4疗法(αCTLA-4),...
Tprog细胞被认为是响应PD-1阻断剂药物的主要细胞。然而， 这一个过程中的细胞外信号和细胞内转录调控机制仍缺乏系统和深入的研究。2023年10月20日，董晨团队在Science Immunology杂志在线发表了题为 BCL6 promotes a stem-like CD8+ T cell program in cancer via antagonizing BLIMP1 的研究论文。该研究详细阐述了...
使用PhenoGraph算法进行聚类分析发现,前者主要由1(C1)和4(C4)簇组成(图1d,右),识别出分别表达T-bet和PD-1的CD27效应记忆T细胞,以及表达GZMB的CD27效应记忆T细胞(图1d,e)。这些簇表达记忆标记物CD127和转录因子LEF1,两者对于CD8+ T细胞的长期持久性都很重要。根据这些数据,作者通过RNA测序(RNA-seq)观察到,与...
(F) Heatmap of the Phenograph clusters of CD8+ cells. The relative expression levels of markers across cells were shown. (G) The frequency of PD-L1+, PD-1+, CD38+, and CD39+ in CD8+ T cells in adjacent and tumor tissues is determined by IMC. N = 9, two tailed paired t-test....