Objective:To explore the effects of tumor necrosis factor-β(TNF-β)on damage of hematopoietic cells by CD8+HLA-DR+ effector T cells of the patients with severe aplastic anemia(SAA),and to prove the role of TNF-β in immunopathogenesis of SAA.Methods:CD8+HLA-DR+ T cells as effector cells...
MHC I 类分子存在于所有有核细胞的细胞表面,是主要的两类 MHC 分子之一。 这些分子不存在于红细胞中,但存在于血小板中。 MHC I 类分子检测细胞内非自身蛋白的蛋白片段。 这些蛋白质片段被称为抗原。 MHC I 分子检测到的非自身抗原位于 Tc 细胞上。 Tc 细胞具有辅助受体分子 CD8。 MHC I 分子,可在 CD8 受体...
与此类似,Paret等【15】根据53%的TNBC患者癌细胞表达CXorf61蛋白这一特点,构建CXorf61的RNA编码逆转录病毒并转染树突状细胞,再将其与人CD8阳性T细胞共培养可获得特异性识别CXorf61的66-74表位CD8阳性T细胞;并且,他们继续用CXorf61的RNA编码逆转录病毒接种于人白细胞抗原(HLA)-A*02转基因小鼠,在小鼠体内亦获得CXo...
Cancer is one of the most concerning public health issues and breast cancer is one of the most common cancers in the world. The immune cells within the tumor microenvironment regulate cancer development. In this study, single immune cell data sets were u
In the acute phase of COVID-19, SARS-CoV-2-specific MHC-I multimer+CD8+T cells express activation markers (CD38 and HLA-DR), Ki-67, IRs (PD-1, TIM-3, and LAG-3), and cytotoxic proteins (perforin and granzyme B), indicating that these cells are activated and proliferate with a ...
Inatsuki A, Yasukawa M, Kobayashi Y. The effect of human T cell leukaemia virus type I infection on a herpes simplex virus-specific CD8+ cytotoxic T cell clone. Br J Haematol. 1991;77:311-314.Yasukawa M, Ohminami H, Kaneko S, Yakushijin Y, Fujita S. Establishment of HLA-DR ...
由HLA-A、B、C等基因编码 E. 可与CD8分子结合 点击查看答案&解析 手机看题 你可能感兴趣的试题 问答题 简述如何对中小学生进行记忆力的训练。 答案: 正确答案:重复记忆。重复是学习之母,尤其像字词、术语、外语单词、历史年代、事件等枯燥乏味的东西,更需要循环往复地记忆。早... 点击查看答案&解析 手机...
The purpose of this study was to clarify whether HLA-DR expression of colorectal tumour cells or the CD4+/CD8+ ratio of the tumour infiltrating lymphocytes
In this study, we analyzed C D38+ HLA-DR+ CD8+ (activated C D8+, aCD8+) T cells in the blood and its correlations with disease parameters of pSS patients. IFN-γ is necessary for activating Th1 cells which activate C D8+ T cells by secreting IFN-γ, and in ...
关于HLA-Ⅱ类抗原分子,正确的是 A. <br/> 由α链和β2m链组成 B. <br/> 呈递外源性抗原 C. <br/> 分布在所有有核细胞的表面 D. <br/> 由HLA A、B、C等基因编码