Cross-linking HLA-DR molecules on Th1 cells induces anergy in association with increased level of cyclin-dependent kinase inhibitor p27(Kip1). Immunol Lett. 2002;81:149–155. Article CAS Google Scholar Tham EL, Shrikant P, Mescher MF . Activation-induced nonresponsiveness: a Th-dependent ...
Neoadjuvant chemotherapy, Breast cancer, Zoledronic acid, Tumor-infiltrating lymphocytes, HLA class 1, Pathological complete responsePurposeTumor-infiltrating lymphocytes (TILs) are associated with pathological complete response (pCR) and survival after neoadjuvant chemotherapy (NAC) in patients with early ...
T-cells play an important role controlling immunity against pathogens and therefore influence the outcome of human diseases. Although most T-lymphocytes co-express either CD4 or CD8, a smaller T-cell subset found the in the human peripheral blood that ex
(CD8A, GNLY, GZMA, GZMB), T-cell trafficking (CXCL9, CXCL10, CCL4, CCL5), and major histocompatibility complex class I (MHC I) (TAP1, TAP2, HLA.A, HLA.B, HLA.C); in contrast, these patients exhibited the lowest expression of tumor proliferation signatures (PLK1, AURKA, CCNB1) (...
Cells from three DN-ATL patients had CD25 antigens, whereas the expression of HLA-DR antigens on cells from any of the four patients was very low, a similar finding to typical acute CD4+ ATL.7 Cells from all three acute DN-ATL patients were CD3+, but the MFI values were extremely ...
Recent studies have highlighted the distinct ratio of PD-1 + Treg/PD-1 + CD8 for prognosis prediction. However, it remains unclear about the association of this ratio and tertiary lymphoid structures (TLS) with prognosis and response to neoad
HLA-DR (clone L243) 174Yb Fluidigm Cat# 3174001; RRID: AB_2665397 CD56 (clone NCAM 16.2) 176Yb Fluidigm Cat# 3176008; RRID: AB_2661813 CD11b (clone ICRF44) 209Bi Fluidigm Cat# 3209003; RRID: AB_2687654 Human Fc Receptor Binding Inhibitor Thermo Fisher Scientific Cat# 14-9161-73; RRID...
In the acute phase of COVID-19, SARS-CoV-2-specific MHC-I multimer+CD8+T cells express activation markers (CD38 and HLA-DR), Ki-67, IRs (PD-1, TIM-3, and LAG-3), and cytotoxic proteins (perforin and granzyme B), indicating that these cells are activated and proliferate with a ...
The autoimmune immunopathology occurring in multiple sclerosis (MS) is sustained by myelin-specific and -nonspecific CD8+ T cells. We have previously shown that, in MS, activated T cells undergoing apoptosis induce a CD8+ T cell response directed against
Tumor-resident T cells display a functionally impaired effector/memory (Tem) phenotype. Sustained intratumoral administration of IL-12, on the other hand, can restore cytolytic function to pre-existing CD8+Tem, resulting in effective tumor kill. Whereas cytotoxic T lymphocytes (CTL) are generally as...