FoxP3 CD8 Tumor-immune infiltration Colorectal cancer Cancer prognosisImmune cells are known to affect clinical outcome in colorectal cancer. Subsets of immune cells can both support and inhibit immunological interaction with tumor cells. We examined the clinical impact of T cells that are supposed to...
Chestnut Studying 摘要 CD8+ T cells control tumors but inevitably become dysfunctional in the tumor microenvironment. Here, we show that sodium chloride (NaCl) counteracts T cell dysfunction to prom…
CD8+ Foxp3+ Regulatory T Cells Mediate Immunosuppression in Prostate Cancer CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancer. Clin Cancer Res 2007; 13:6947-58.Kiniwa Y, Miyahara Y, Wang HY, Peng W... Y Kiniwa,Y Miyahara,HY Wang,... - 《Clinical Cancer ...
Besides CD4 regulatory T-cells (Tregs), immunosuppressor FoxP3 + CD8 T-cells are emerging as an important subset of Tregs, which contribute to immune dysfunction and disease progression in HIV infection. However, FoxP3 + CD8 T-cell dynamics in acute HIV infection and following early antiretrovir...
Transient rises inPD-1+Foxp3+ Treg and potentially anergic (CD57−KLRG1−PD-1+) cells in the circulating CD4 T cell compartment were paralleled by more profound increases in circulating CD8 T cells with traits of exhaustion (CD57−KLRG1+PD-1+,TIGIT+...
Transient rises inPD-1+Foxp3+ Treg and potentially anergic (CD57−KLRG1−PD-1+) cells in the circulating CD4 T cell compartment were paralleled by more profound increases in circulating CD8 T cells with traits of exhaustion (CD57−KLRG1+PD-1+,TIGIT+KLRG1+, and persistent down-modulation...
根据先前的研究,在CD3T细胞中,Foxp3调节性T细胞的绝对数量和CD4T细胞总数的百分比增加。相反,两个绝对数和频率随着时间的推移,CD8+T细胞明显下降,而它们逐渐获得功能衰竭的特征,这是由耗竭标记的上调所表明的,包括PD1和TIM3和降低产生效应细胞因子和分子的能力,如IFNγ和颗粒酶β。因此,PDA能够招募初始CD8+T细胞免疫...
在各种实体瘤患者中,免疫细胞特定亚型的出现与临床反应有重要的相关性[[url=]6[/url]],其中乳腺癌的大量肿瘤浸润性CD8+细胞毒T细胞(cytotoxic T cell,CTL)与患者生存期[[url=]7[/url]]及对治疗的反应密切相关[[url=]8[/url]],指叉头框蛋白3(FOXP3)阳性调节性T细胞(regulatory cells,Treg)在抑制抗肿瘤...
Transient rises inPD-1+Foxp3+ Treg and potentially anergic (CD57−KLRG1−PD-1+) cells in the circulating CD4 T cell compartment were paralleled by more profound increases in circulating CD8 T cells with traits of exhaustion (CD57−KLRG1+PD-1+,TIGIT+KLRG1+, and persistent down-modulation...
结论:CD8 + CD28 - Foxp3 + Tregs 在肝癌患者外周血及癌组织中增多,可能与肿瘤免疫抑制作用有关,其检测对肝癌患者病情有一定评估价值。 关键词 癌,肝细胞;T 淋巴细胞,调节性;叉头转录因子类 中图分类号:R735.7 Changes in CD8 + CD28 – Foxp3 + regulatory T cells in patients with hepatocellular ...