Firstly, identification of specific biomarkers in cancers may help predict the patient outcomes when treated using ICIs. Examining CD14+CD16b−HLA-DRhiin peripheral blood can increase the screening frequency of PD-1 mAb-sensitive stage IV melanoma patient [97]. Lately, breast cancer susceptibility ...
aFlow cytometry contour plots of the MHC-II+CD11c+DC population in tumors of WT andBatf3−/−mice on day 14 after A20.GL intravenous injection. Gates highlight CD11b+CD103−cDC2 (blue) and CD11b−CD103+cDC1 (green) cells. Percentage of CD11b−CD103+cDC1s in WT andBatf3−...
naive CD8+T cells, but also establish CTLs in the TME, and it’s the mediator that transport solid tumor antigens from TME to tumor draining lymph nodes for CD8+T cells. The Cancer Genome Atlas (TCGA) database analysis indicated that CD103+/CD103−is strongly correlates with cancerous ...
Furthermore, various LCK-dependent methods, such as CD61 and CD103 co-localization with TCR [158], CD146 homodimer-induced LCK autophosphorylation [159], and disulfiram increasing LCK kinase activity [160], have been shown to enhance proximal TCR signal transduction. Distal signal transduction of...
Recently, a few studies reported that CD94 was associated with the regulatory function of NK cells and CD8+T cells. Della Chiesa and coworkers[16] found that a NK cell subset expressing CD94-NKG2A in lymph nodes was capable of killing immature DC and mature DC to prevent the ...
CD45RA PD-1+ Gated on CD45RA– CD8+ T cells TFLN Tumour 92.5% 62.0% 100 P=0.0578 P = 0.0093 PD-1– 80 75.3 81.9 72.6 PD-1+ 60 61.6 40 00 100 101 102 103 104 100 101 102 103 104 83.6% 73.7% PD-1– 20 0 TFLN Tumour 2500 P =0.2208 P=0.0259 2000 1500 1538 1631 00 ...
作者测量了PD-L1在肿瘤不同细胞上的表达水平。DC,尤其是CD103+DC,在体内表达最高水平的PD-L1,这可能有助于PD-L1×CD3的DC靶向性。这些结果表明,作者的治疗可能通过DC的独特子集改善CD8 T细胞功能(图4d)。综上所述,CD103+cDC1上的PD-L1在促进PD-L1×CD3治疗的抗肿瘤效果方面起着关键作用。
https://doi.org/10.1016/j.celrep.2021.109696Get rights and content Under a Creative Commons license open accessHighlights Summary CD4 T cells are essential for immunity to tuberculosis because they produce cytokines, including interferon-γ. Whether CD4 T cells act as “helper” cells to promote ...
This review describes the pedigree of CD8α(+) DCs and related subsets, including a history of the discovery of DC subsets and their functional characterization.doi:10.1007/s10059-012-0058-6The bloodline of...
K. et al. The developmental pathway for CD103(+)CD8+tissue-resident memory T cells of skin. Nat Immunol 14, 1294–1301 (2013). 17. Wakim, L. M. et al. The molecular signature of tissue resident memory CD8 T cells isolated from the brain. J Immunol 189, 3462–3471 (2012)...