研究者通过对比慢性乙型肝炎、非酒精性脂肪性肝病和健康人的组织,发现AIH患者肝内CD69+ CD103+ CD8+ TRM 细胞显著增加,且与疾病严重程度呈正相关。AIH患者肝内IL-15和TGF-β表达水平显著升高,且肝细胞广泛表达CD103配体- E-钙黏蛋白(E-cadherin),这些因素可能有助于CD8+ TRM细胞的分化和驻留。经过免疫治疗后,...
Renal CD8+ tissue-resident memory T (TRM) cells display prolonged survival and activity in lupus nephritis (LN), exacerbating renal pathology. NLRP3 regulates the T cell response. This study explored the impact of NLRP3 inflammasome activity on the regul
transcription factors were predicted using the UCSC and JASPAR databases.We found that different CD8 + TRM subsets existed in CRC tumor tissues, which were identified as CD69 CD103 CD8 + TRM, CD69 + CD103 CD8 + TRM (SP CD8 + TRM), and CD69 + CD103 + CD8 + TRM (DP CD8 + TRM)...
3.4.1CD69 and CD103 According to recent studies,CD69is considered to play a key function in retaining TRM cells in tissues whereas CD103 expressed by TRM cells interact with E-cadherin on the epithelial cells in order to promote resident phenotype in TRMT cells[28,73,74]. Recent studies ...
CD8+TRM 样细胞的作用:对术后样本进行 RNA 测序和免疫浸润分析,发现 nICT 组 pCR 患者的 CD8+T 细胞、中性粒细胞和细胞毒性 T 细胞(Tc)浸润显著增加,且 nICT 组中 CD69 基因及一些 T 细胞共抑制分子表达升高。通过对 TCGA 泛癌数据集的分析,发现 CD69 高表达与更好的 DFS 相关(P<0.001),而 CD103 未...
transcription factors were predicted using the UCSC and JASPAR databases.We found that different CD8 + TRM subsets existed in CRC tumor tissues, which were identified as CD69 CD103 CD8 + TRM, CD69 + CD103 CD8 + TRM (SP CD8 + TRM), and CD69 + CD103 + CD8 + TRM (DP CD8 + TRM)...
Background & aims: Tissue-resident memory T cells (Trm), both of the CD4 and CD8 lineage, have been implicated in disease flares in inflammatory bowel disease. However, data is conflicting regarding the profile of human CD8+ Trm, with st... L Lutter,B Roosenboom,EC Brand,... - 《Cellu...
目的:本研究从人和动物两个层面探究银屑病皮损中组织常驻记忆CD8+T(TRM)细胞数目和分布及其驻留相关因子CD103,CD69和CD49a的特征,同时观察加味凉血消风散(LXXF)治疗寻... 王秋月 - 成都中医药大学 被引量: 0发表: 2022年 加载更多来源期刊 国际皮肤性病学杂志 研究点推荐 银屑病皮损 CD69+T细胞 银屑病患者...
Recently, tissue-resident memory T cells (TRM) cells in tissue-specific immune and inflammatory diseases is beginning to be appreciated. However, CD8+TRM cells have not been fully elucidated regarding their changes and functions in human intestinal aGVHD. In this study, we used CD69 and CD103 ...
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