AIH患者肝内IL-15和TGF-β表达水平显著升高,且肝细胞广泛表达CD103配体- E-钙黏蛋白(E-cadherin),这些因素可能有助于CD8+ TRM细胞的分化和驻留。经过免疫治疗后,AIH患者肝内CD8+ TRM细胞数量显著下降。糖皮质激素可以通过直接下调CD8+ TRM细胞Blimp1的表达,从而抑制CD8+ TRM细胞的体外扩增。 该研究证实了CD69+...
and the functioning transcription factors were predicted using the UCSC and JASPAR databases.We found that different CD8 + TRM subsets existed in CRC tumor tissues, which were identified as CD69 CD103 CD8 + TRM, CD69 + CD103 CD8 + TRM (SP CD8 + TRM), and CD69 + CD103 + CD8 + TRM...
and the functioning transcription factors were predicted using the UCSC and JASPAR databases.We found that different CD8 + TRM subsets existed in CRC tumor tissues, which were identified as CD69 CD103 CD8 + TRM, CD69 + CD103 CD8 + TRM (SP CD8 + TRM), and CD69 + CD103 + CD8 + TRM...
3.4.1 CD69 and CD103 According to recent studies, CD69 is considered to play a key function in retaining TRM cells in tissues whereas CD103 expressed by TRM cells interact with E-cadherin on the epithelial cells in order to promote resident phenotype in TRM T cells [28,73,74]. Recent ...
Renal CD8+ tissue-resident memory T (TRM) cells display prolonged survival and activity in lupus nephritis (LN), exacerbating renal pathology. NLRP3 regulates the T cell response. This study explored the impact of NLRP3 inflammasome activity on the regul
332 CD69+CD103+ CD8 resident memory T cells with the potential of producing interleukin-17 are enriched in both lesional and non- lesional skin of psoriasis patientsHIV-associated psoriasis appears paradoxical, being a T-cell mediated ... S Vo,R Watanabe,Y Matsumura,... - 《Journal of Inve...
目的 探讨银屑病患者皮肤CD69+T细胞的表达及其与疾病活动性的关系.方法 免疫组化检测31例银屑病患者皮损和非皮损中CD69+T细胞在皮肤中的表达,与6例健康人进行对照.结果 CD69+T细胞主要分布于皮肤真皮.31例银屑病患者皮损和非皮损的真皮中,CD69+T细胞分别为(35.16±12.67)%和(8.70±3.29)%,皮损明显高于非皮损(...
ARTICLE Received 17 Apr 2016 | Accepted 7 Oct 2016 | Published 23 Nov 2016 DOI: 10.1038/ncomms13478 OPEN VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination Yuki Miyamoto1, Tomohiro Torii1, Akito Tanoue1 & Junji Yamauchi1,2 Oligodendrocytes ...
et al. Intestinal CD103 þ , but not CX3CR1 þ , antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J. Exp. Med. 206, 3101–3114 (2009). This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported ...
Tissue-resident memory (Trm) CD8+ T cells expressing CD69+CD103+ increase in number ~12 days following the first and second doses, by 0.31 and 0.43... A Ssemaganda,HM Nguyen,F Nuhu,... - 《Nature Communications》 被引量: 0发表: 2022年 The biology of CD4+ T cells in the blood ...