AIH患者肝内IL-15和TGF-β表达水平显著升高,且肝细胞广泛表达CD103配体- E-钙黏蛋白(E-cadherin),这些因素可能有助于CD8+ TRM细胞的分化和驻留。经过免疫治疗后,AIH患者肝内CD8+ TRM细胞数量显著下降。糖皮质激素可以通过直接下调CD8+ TRM细胞Blimp1的表达,从而抑制CD8+ TRM细胞的体外扩增。 该研究证实了CD69+...
In patients with LC, the activation and increased function of liver CD69+CD103 CD8+ T cells were associated with their HIF-2α expression, which could be controlled by HIF-2α inhibition. In summary, we show that human liver CD69+CD103CD8+ T cells showed terminally differentiated tissue ...
3.4.1CD69 and CD103 According to recent studies,CD69is considered to play a key function in retaining TRM cells in tissues whereas CD103 expressed by TRM cells interact with E-cadherin on the epithelial cells in order to promote resident phenotype in TRMT cells[28,73,74]. Recent studies ...
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et al. Intestinal CD103 þ , but not CX3CR1 þ , antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J. Exp. Med. 206, 3101–3114 (2009). This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported ...
et al. The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin. Nat. Immunol. 14, 1294–1301 (2013). Article CAS PubMed Google Scholar Awasthi, A. et al. Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells. J. ...
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