AIH患者肝内IL-15和TGF-β表达水平显著升高,且肝细胞广泛表达CD103配体- E-钙黏蛋白(E-cadherin),这些因素可能有助于CD8+ TRM细胞的分化和驻留。经过免疫治疗后,AIH患者肝内CD8+ TRM细胞数量显著下降。糖皮质激素可以通过直接下调CD8+ TRM细胞Blimp1的表达,从而抑制CD8+ TRM细胞的体外扩增。 该研究证实了CD69+...
In patients with LC, the activation and increased function of liver CD69+CD103 CD8+ T cells were associated with their HIF-2α expression, which could be controlled by HIF-2α inhibition. In summary, we show that human liver CD69+CD103CD8+ T cells showed terminally differentiated tissue ...
CD8+TRM 样细胞的作用:对术后样本进行 RNA 测序和免疫浸润分析,发现 nICT 组 pCR 患者的 CD8+T 细胞、中性粒细胞和细胞毒性 T 细胞(Tc)浸润显著增加,且 nICT 组中 CD69 基因及一些 T 细胞共抑制分子表达升高。通过对 TCGA 泛癌数据集的分析,发现 CD69 高表达与更好的 DFS 相关(P<0.001),而 CD103 未...
Renal CD8+ tissue-resident memory T (TRM) cells display prolonged survival and activity in lupus nephritis (LN), exacerbating renal pathology. NLRP3 regulates the T cell response. This study explored the impact of NLRP3 inflammasome activity on the regul
Previous work from our laboratory has demonstrated in vivo persistence of CD103+CD69+brain resident memory CD8+T‐cells (bTRM) following viral infection, and that the PD‐1: PD‐L1 pathway promotes development of these TRMcells within the brain. Although glial cells express low basal levels of...
+T细胞等免疫细胞的有效评分低于对照组,差异均有统计学意义(均P<0.05).对照组交界区内CD8+CD69+T与CD4+CD69+CD103+T细胞的距离相较于免疫治疗组更近,差异有统计学意义(t=2.67,P= 0.009).结论肝细胞癌患者免疫治疗后癌组织PD-1+细胞减少,CD8+CD69+T细胞周围的免疫细胞减少,这种变化与CD8+CD103+T细胞距离...
3.4.1CD69 and CD103 According to recent studies,CD69is considered to play a key function in retaining TRM cells in tissues whereas CD103 expressed by TRM cells interact with E-cadherin on the epithelial cells in order to promote resident phenotype in TRMT cells[28,73,74]. Recent studies ...
Compared to healthy controls, the absolute number of CD8+ T cells in the intestinal tissues of aGVHD patients was significantly increased(Figure D), while the absolute number and proportion of CD8+CD69+CD103+ TRM cells were significantly decreased (P<0.0001)(Figure E),. Furthermore, patients ...
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