AIH患者肝内IL-15和TGF-β表达水平显著升高,且肝细胞广泛表达CD103配体- E-钙黏蛋白(E-cadherin),这些因素可能有助于CD8+ TRM细胞的分化和驻留。经过免疫治疗后,AIH患者肝内CD8+ TRM细胞数量显著下降。糖皮质激素可以通过直接下调CD8+ TRM细胞Blimp1的表达,从而抑制CD8+ TRM细胞的体外扩增。 该研究证实了CD69+...
In patients with LC, the activation and increased function of liver CD69+CD103 CD8+ T cells were associated with their HIF-2α expression, which could be controlled by HIF-2α inhibition. In summary, we show that human liver CD69+CD103CD8+ T cells showed terminally differentiated tissue ...
3.4.1CD69 and CD103 According to recent studies,CD69is considered to play a key function in retaining TRM cells in tissues whereas CD103 expressed by TRM cells interact with E-cadherin on the epithelial cells in order to promote resident phenotype in TRMT cells[28,73,74]. Recent studies ...
CD8+TRM 样细胞的作用:对术后样本进行 RNA 测序和免疫浸润分析,发现 nICT 组 pCR 患者的 CD8+T 细胞、中性粒细胞和细胞毒性 T 细胞(Tc)浸润显著增加,且 nICT 组中 CD69 基因及一些 T 细胞共抑制分子表达升高。通过对 TCGA 泛癌数据集的分析,发现 CD69 高表达与更好的 DFS 相关(P<0.001),而 CD103 未...
Compared to healthy controls, the absolute number of CD8+ T cells in the intestinal tissues of aGVHD patients was significantly increased(Figure D), while the absolute number and proportion of CD8+CD69+CD103+ TRM cells were significantly decreased (P<0.0001)(Figure E),. Furthermore, patients ...
and the functioning transcription factors were predicted using the UCSC and JASPAR databases.We found that different CD8 + TRM subsets existed in CRC tumor tissues, which were identified as CD69 CD103 CD8 + TRM, CD69 + CD103 CD8 + TRM (SP CD8 + TRM), and CD69 + CD103 + CD8 + TRM...
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