绝大多数siIEL CD8+ TRM细胞都表达高水平的CD69和CD103。 约60%的siLPL TRM细胞同时表达CD69和CD103; cIEL和cLPL TRM细胞则很少同时表达二者。 大多数siLPL和cLPL TRM细胞仅表达CD69; 部分cIEL和cLPL TRM细胞既不表达CD69,也不表达CD103。 Immunity. 2023 Jan 10;56(1):207-223.e8. CXCR和CCR9: 与...
自身免疫性肝炎 (AIH) 患者的肝脏中存在多种炎症反应,但对潜在致病亚群的鉴定仍缺乏有效的生物标志物。 研究者通过对比慢性乙型肝炎、非酒精性脂肪性肝病和健康人的组织,发现AIH患者肝内CD69+ CD103+ CD8+ TRM 细胞显著增加,且与疾病严重程度呈正相关。AIH患者肝内IL-15和TGF-β表达水平显著升高,且肝细胞广泛表...
前体记忆T细胞在促炎细胞因子(如I型干扰素)的影响下,进入肿瘤部位并进一步成熟。一群记忆前体细胞将进一步分化为CD103 CD69组织驻留记忆T(TRM)细胞。 与位于肿瘤微环境中的其他T细胞不同,TRM细胞保留在肿瘤组织中,不再循环。CD103与上皮细胞E-钙粘蛋白结合有助于驻留。 活化的TRM细胞具有识别肿瘤细胞表面表达的肿瘤...
近期,研究者对小鼠乳腺肿瘤的表型和转录研究建立了两个瘤内亚群:一个是具有更丰富的终极衰竭标志物(TEX型,CD69+CD103-CD8+T细胞),另一个是具有真正的常驻表型(TRM型,CD69+CD103+CD8+T细胞)(图10)(Virassamy et al., 2023)。抗PD -1和抗CTLA-4治疗...
Whilst epithelial CD8(+) TRM cells co-express CD69 and CD103, CD103(-) memory cells have been described in various organs and are often presumed non-recirculating based on their expression of CD69. We found that both CD69(+)CD103(+) and CD69(+)CD103(-) memory cells populated the ...
CD103glial cellsPD‐L1IntroductionPrevious work from our laboratory has demonstrated in vivo persistence of CD103+CD69+ brain resident memory CD8+ T‐cells (bTRM) following viral infection, and that the PD‐1: PD‐L1 pathway promotes development of these TRM cells within the brain. Although ...
332 CD69+CD103+ CD8 resident memory T cells with the potential of producing interleukin-17 are enriched in both lesional and non- lesional skin of psoriasis patientsHIV-associated psoriasis appears paradoxical, being a T-cell mediated ... S Vo,R Watanabe,Y Matsumura,... - 《Journal of Inve...
survival in patients with cancer, we performed multicolor flow cytometric profiling of tumors from 19 patients with NSCLC. We first stratified the CD61+and CD61−TRMTILs according to the well-established tissue-resident memory TIL phenotype of CD103+CD69+CD49a+CD45RO+(CD62L−CCR7−CD45...
namely the IL-18bp.69 Although the function of IL-18 in gut inflammation is controversial,70 it is clear that blocking its activity attenuates intestinal damage.24,71 The imbalance of the IL-18/ IL-18bp ratio could lead to higher levels of active IL-18 resulting in exacerbation of intestin...
The CD103+CD69+ TRM cell numbers and CD103 MFI were increased by Tcf7 deficiency. The percentages of BrdU+ T cells were reduced in the Tcf7-deficient P14 T cells. Additionally, GP33-41 peptide stimulation-induced cytokine production was increased by Tcf7 deficiency (Figures 4A, 4B, and ...