绝大多数siIEL CD8+ TRM细胞都表达高水平的CD69和CD103。 约60%的siLPL TRM细胞同时表达CD69和CD103; cIEL和cLPL TRM细胞则很少同时表达二者。 大多数siLPL和cLPL TRM细胞仅表达CD69; 部分cIEL和cLPL TRM细胞既不表达CD69,也不表达CD103。 Immunity. 2023 Jan 10;56(1):207-223.e8. CXCR和CCR9: 与...
自身免疫性肝炎 (AIH) 患者的肝脏中存在多种炎症反应,但对潜在致病亚群的鉴定仍缺乏有效的生物标志物。 研究者通过对比慢性乙型肝炎、非酒精性脂肪性肝病和健康人的组织,发现AIH患者肝内CD69+ CD103+ CD8+ TRM 细胞显著增加,且与疾病严重程度呈正相关。AIH患者肝内IL-15和TGF-β表达水平显著升高,且肝细胞广泛表...
Although CD103 cells were weaker effectors on a per cell basis than CD103+ cells following T-cell receptor or interleukin-15 stimulation, they remained the major CD69+CD8+ effector population in the liver, surviving with less cell death. HIF-2α inhibitor or knockdown suppressed the effector ...
近期,研究者对小鼠乳腺肿瘤的表型和转录研究建立了两个瘤内亚群:一个是具有更丰富的终极衰竭标志物(TEX型,CD69+CD103-CD8+T细胞),另一个是具有真正的常驻表型(TRM型,CD69+CD103+CD8+T细胞)(图10)(Virassamy et al., 2023)。抗PD -1和抗CTLA-4治疗...
CD103glial cellsPD‐L1IntroductionPrevious work from our laboratory has demonstrated in vivo persistence of CD103+CD69+ brain resident memory CD8+ T‐cells (bTRM) following viral infection, and that the PD‐1: PD‐L1 pathway promotes development of these TRM cells within the brain. Although ...
Renal CD8+ tissue-resident memory T (TRM) cells display prolonged survival and activity in lupus nephritis (LN), exacerbating renal pathology. NLRP3 regulates the T cell response. This study explored the impact of NLRP3 inflammasome activity on the regul
Compared to healthy controls, the absolute number of CD8+ T cells in the intestinal tissues of aGVHD patients was significantly increased(Figure D), while the absolute number and proportion of CD8+CD69+CD103+ TRM cells were significantly decreased (P<0.0001)(Figure E),. Furthermore, patients ...
Previous work from our laboratory has demonstrated in vivo persistence of CD103+CD69+brain resident memory CD8+T‐cells (bTRM) following viral infection, and that the PD‐1: PD‐L1 pathway promotes development of these TRMcells within the brain. Although glial cells express low basal levels of...
在探究功能时,研究起初依照 CD103+CD69+CD49a+CD45RO+ (CD62L?CCR7?CD45RA?) CD8+ TILs 这一被广泛认可的组织驻留记忆 TILs 表型,对 CD61 + 和 CD61? TILs 予以分类。 实验结果表明,CD61+ TILs 中关键的抗肿瘤效应因子,诸如细胞因子、趋化因子以及溶瘤分子,均出现显著上调现象。此外,研究还证实了 CD...
and the functioning transcription factors were predicted using the UCSC and JASPAR databases.We found that different CD8 + TRM subsets existed in CRC tumor tissues, which were identified as CD69 CD103 CD8 + TRM, CD69 + CD103 CD8 + TRM (SP CD8 + TRM), and CD69 + CD103 + CD8 + TRM...