Using tissue microarrays from a retrospective cohort of TNBC patients from St George Hospital, Sydney (n=244), multiplexed immunofluorescence (mIF) was used to assess staining for CD3, CD8, CD20, CD68, PD-1, PD-
2 3例患者肿瘤免疫微环境结果提示:病例1cd8+淋巴细胞高度浸润,pd-l1阳性细胞在cd68+巨噬细胞中占比超过80% 使用臻和朗蒂思对3例患者肿瘤组织的免疫微环境进行检测。病例1肿瘤区cd8+和cd8+pd-1+ t细胞的百分比分别为8.6%和2.7%,间...
对于PD-L1在CD68+巨噬细胞上的表达水平,X-Tile将其最佳截断值设为65%,CD68+细胞上PD-L1高表达的(n=47)患者OS略好于低表达35%(n=26),但无统计学意义(p=0.097)(图4C)。检测CD163+巨噬细胞上PD-L1的表达,X-Tile将其最佳截断点设...
Interestingly, intracellular levels of IL-10, IL-6, TNF-伪, and IFN-纬 in PD-L1+CD68+ macrophage were higher than those in PD-L1鈭扖D68+ macrophage, especially IL-6 expression. Based on the PD-L1 receptor PD-1 expression on tumor-infiltrating cytotoxic cells, our data supported that ...
学术学位硕±学位论文 学校代码:10678 分类号:R739.5R365R349.7 学号;2013028 密级: 見略S种A常 硕±学位论文 馨 PD-L1、BRAFW00E、CD68 蛋白表达 与恶性黑色素瘤的关系及意义 院(系
Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation Authors - Huan Tong View Article Cell Metab Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species. Authors - Xiao...
For example, the PD-1/PD-L1 signaling pathway plays a vital role in the inhibition of immune responses and induction of apoptosis. Several studies have indicated that specific antibodies or drugs that target the PD-1/PD-L1 axis can effectively promote antitumor immunotherapy and lead to a ...
PD-L1 (E1L3N®) XP® Rabbit mAb #13684 20 µl Immunosuppressive Tumor Microenvironment IHC Antibody Sampler Kit #67524 1 Kit Product Information Product Description This Cell Signaling Technology antibody is conjugated to phycoerythrin (PE) and tested in-house for direct flow ...
PD-L1和CD68的表达与上皮性卵巢癌高危风险及预后关系的研究 热度: IgA肾病尿液补体与临床及病理特征关系的研究 热度: - 640· 中国临床保健杂志 2011年12月第l4卷第6期 ChinJClinHealthc,December201l,Vo1.14,NO.6 IgA肾病肾组织CI~i8表达与病理类型的关系 ...
三阴性乳腺癌 (TNBC) 约占乳腺癌的10-15%,预后差,5年内复发风险高。PD-L1是TNBC患者免疫治疗的重要预测标志物,但其在肿瘤免疫微环境中的细胞表达、共定位以及预后价值尚未明确。 为了表征表达PD-L1的免疫细胞表型,并确定它们与总生存率(OS)、乳腺癌特异性生存率(BCSS)的关联性,悉尼圣乔治医院回顾性研究了244...