一些用于识别人类初始和记忆T细胞亚群的标记物,如CD45RA不适合用于鼠类T细胞亚群的表型。在小鼠中使用CD44、CD62L和CCR7等标记物来识别初始(Tn)、中央记忆(Tcm)和效应记忆(Tem)/效应(Teff)亚群,以及KLRG1和CD127,用于识别记忆前体效应细胞(MPEC)和短寿命效应...
非小细胞肺癌中CCR7和CD62L表达及与淋巴结转移的关系
CD45RO、CCR7、CD62L荧光抗体染色,用流式细胞仪进行检测各表面标志的表达情况。 结果: 1、乙肝肝癌组、乙肝癌旁组及对照组CD4 + T细胞占浸润淋巴细胞的比例分别为 (21.38±3.72)%、(10.12±2.42)%、(4.14±4.34)%。乙肝肝癌组显著高于乙肝癌旁组及 ...
预后不良组患者的外周血KLF2mRNA 、CD62L 表达水平分别为0.31±0.12、(45.30±10.85)%，明显低于预后良好组的0.54±0.15、(60.49±14.12)%，CCR7mRNA 表达水平为3.01±0.48，明显高于预后良好组的1.84±0.43，差异均有统计学意义(P <0.05)；经多因素Logistic 回归分析结果显示，合并高血压、合并...
目的探讨CC趋化因子受体7(CCR7)和L-选择素(CD62L)在非小细胞肺癌(NSCLC)组织中的表达及其与淋巴结转移的关系.方法采用免疫组化法检测80份NSCLC癌组织和20份癌旁正常肺组织标本中CCR7和CD62L表达,比较二者在淋巴结转移者与无淋巴结转移者中的阳性表达率.结果NSCLC癌组织中CCR7和CD62L表达阳性率均明显高于癌旁...
CD4~+ CD62L~+CCR7~+中枢记忆性T细胞诱导功能性Foxp3~+调节性T细胞 背景:Treg在体内根据产生部位不同可以分为natural Treg细胞(n Treg)和induced Treg细胞(i Treg).对于n Treg细胞在体内的起源和产生目前已经有了比较清楚的认识,认为n Treg细胞是在胸腺内产生,对维持自身免疫耐受具重要作用.然而对于i Tre...
After two and four hours of incubation, the expression of CD62L and CCR7 on CD4+ and CD8+ na篓ve T cells was examined via flow cytometry. Preliminary results show that the MR antagonist reduced the expression of both CD62L and CCR7. Accordingly, the agonist slightly increased the ...
Three main points emerged: firstly, memory cells frequently expressed a mixed CD62L- CCR7+ phenotype that differed from the phenotypes of classical TEM and TCM cells; secondly, TCM cells were not restricted to lymphoid organs but were also present in significant numbers in nonlymphoid tissues; ...
First, naive T cells express the homing receptors CD62L and CCR7 that allow efficient homing to antigen-rich secondary lymphoid organs, which may lead to activation by aAgs.12, 13, 14, 15 These molecules are down-regulated following T-cell receptor (TCR) activation (leading to egress from ...
CD62L is also expressed on a subset of CCR7highCD44high central memory T cells and on CD4+CD25+ regulatory T cells. Additional information: Clone REA828 displays negligible binding to Fc receptors. Alternative names Sell, L-selectin, LECAM-1, Lnhr, Ly-22, Ly-m22, Lyam-1, Lyam1, LAM...