一些用于识别人类初始和记忆T细胞亚群的标记物,如CD45RA不适合用于鼠类T细胞亚群的表型。在小鼠中使用CD44、CD62L和CCR7等标记物来识别初始(Tn)、中央记忆(Tcm)和效应记忆(Tem)/效应(Teff)亚群,以及KLRG1和CD127,用于识别记忆前体效应细胞(MPEC)和短寿命效应...
非小细胞肺癌中CCR7和CD62L表达及与淋巴结转移的关系
CD45RO、CCR7、CD62L荧光抗体染色,用流式细胞仪进行检测各表面标志的表达情况。 结果: 1、乙肝肝癌组、乙肝癌旁组及对照组CD4 + T细胞占浸润淋巴细胞的比例分别为 (21.38±3.72)%、(10.12±2.42)%、(4.14±4.34)%。乙肝肝癌组显著高于乙肝癌旁组及 ...
预后不良组患者的外周血KLF2mRNA 、CD62L 表达水平分别为0.31±0.12、(45.30±10.85)%，明显低于预后良好组的0.54±0.15、(60.49±14.12)%，CCR7mRNA 表达水平为3.01±0.48，明显高于预后良好组的1.84±0.43，差异均有统计学意义(P <0.05)；经多因素Logistic 回归分析结果显示，合并高血压、合并...
CD4~+ CD62L~+CCR7~+中枢记忆性T细胞诱导功能性Foxp3~+调节性T细胞 背景:Treg在体内根据产生部位不同可以分为natural Treg细胞(n Treg)和induced Treg细胞(i Treg).对于n Treg细胞在体内的起源和产生目前已经有了比较清楚的认识,认为n Treg细胞是在胸腺内产生,对维持自身免疫耐受具重要作用.然而对于i Tre...
目的探讨CC趋化因子受体7(CCR7)和L-选择素(CD62L)在非小细胞肺癌(NSCLC)组织中的表达及其与淋巴结转移的关系.方法采用免疫组化法检测80份NSCLC癌组织和20份癌旁正常肺组织标本中CCR7和CD62L表达,比较二者在淋巴结转移者与无淋巴结转移者中的阳性表达率.结果NSCLC癌组织中CCR7和CD62L表达阳性率均明显高于癌旁...
Further, we identified previously described nave T cells (CCR7+CD95-/or CD62L+CD45RA+) in AML BM and PB samples, which seemed to be required for a successful TILs ex vivo expansion. Finally, we showed that the expanded TILs could: (1) cause cytotoxicity to autologous AML blasts ex ...
Three main points emerged: firstly, memory cells frequently expressed a mixed CD62L- CCR7+ phenotype that differed from the phenotypes of classical TEM and TCM cells; secondly, TCM cells were not restricted to lymphoid organs but were also present in significant numbers in nonlymphoid tissues; ...
First, naive T cells express the homing receptors CD62L and CCR7 that allow efficient homing to antigen-rich secondary lymphoid organs, which may lead to activation by aAgs.12, 13, 14, 15 These molecules are down-regulated following T-cell receptor (TCR) activation (leading to egress from ...
肝癌患者肿瘤浸润淋巴细胞表面标志CD45RO、CCR7和CD62L表达特点分析---优秀毕业论文 参考文献 可复制黏贴 急性白血病患者PTTG基因表达的研究论文 ANRIL不同转录本在冠心病患者外周血的表达及临床意义研究 协同刺激分子ox402fox40l在graves27病患者外周血淋巴细胞的表达与其临床意义 双肺弥漫性病变患者肺泡灌洗液中肺表面...