推荐其采用的方案是CD3、CD4、CD8、CD45RA、CCR7、CD45RO。当然,大家也可以根据自己的喜好选择增加其它标记,例如CD62L、CD95等。 参考资料: T细胞亚群细分标记 T细胞接受抗原刺激后的五个阶段及其表型 T细胞耗竭四阶段 Flynn, J. K. & Gorry, P. R. Stem memory T cells (TSCM)—their role in cancer a...
(2001). Reevaluation of the origin of CD44(high) "memory phenotype" CD8 T cells: comparison between memory CD8 T cells and thymus-independent CD8 T cells. European Journal of Immunology, 31(6), 1917-1926.Yamada H, Matsuzaki G, Chen Q, Iwamoto Y, Nomoto K. Reevaluation of the origin ...
Only the CD8+CD44hi memory T-cell subset containing both central and effector memory cells was capable of eradicating the lymphoma cells without inducing GVHD. In contrast, CD4+and CD8+ naive T cells, memory CD44hi CD4+ T cells, naive total T cells, and memory CD44hi total T cells either...
Host-reactive CD8+ memory stem cells in graft-versus-host disease. The postmitotic CD44loCD62LhiCD8+ T cells persist throughout the course of GVHD, are generated in the initial phase in response to alloantigens and ... Yi,Zhang,Joe,... - 《Nature Medicine》 被引量: 0发表: 2005年 ...
Persistent hepatitis B virus (HBV) infection results in chronic liver diseases that may progress to chronic hepatitis, liver cirrhosis, and subsequent hepatocellular carcinoma. Previous studies demonstrated that adaptive immunity, in particular CD8 T cel
一些研究表明,在衰老T细胞中,乳酸脱氢酶(LDH)活性显著降低,并降低T细胞的增殖。衰老的幼稚CD4+T细胞导致胞外酸化率(ECAR,一种能量代谢指标)减弱,糖酵解和戊糖-磷酸途径中相关的代谢物减少。但是在衰老过程中,幼稚CD8+T细胞的糖酵解是否也会受损尚不清楚。CD4+T细胞中糖酵解的减少可能是由TCR信号阈值的变化(年龄...
CD4 and CD8 T-Cell Lineage Gamma-Delta T cells Stem Cells and Development T Follicular Helper Cell Pathway TH1 Pathway (Cellular Immune Response) TH2 Pathway (Humoral Immune Response) Pages Quality Control Multicolor Staining Guide Fluorescence Spectra Analyzer CD Molecule Chart Fluoroph...
CD44hiCD8+ T cells express T-cell activation markers but are defective in GVHD induction in MHC-matched miHA-mismatched B6 recipient mice, whereas CD44loCD8+ T cells express the phenotypes of naive T cells and are extremely potent inducers of GVHD. Interestingly, CD44hiCD8+ T cells themselves...
CD4 and CD8 T-Cell Lineage Gamma-Delta T cells Stem Cells and Development T Follicular Helper Cell Pathway TH1 Pathway (Cellular Immune Response) TH2 Pathway (Humoral Immune Response) Pages Quality Control Multicolor Staining Guide Fluorescence Spectra Analyzer CD Molecule Chart Fluoroph...
CD44的表達是一個指示標記效應記憶T細胞(effector-memory T-cells)。記憶細胞增殖(活化)也可在體外用CFSE(Carboxyfluorescein succinimidyl ester)化學標記進行檢測。 此外,不同的CD44被發現為可以用於某些乳腺癌(breast cancer)和前列腺癌(prostate cancer)幹細胞的細胞表面標記。在乳腺癌研究CD44 + / CD24-表達的有無...