Yamada H, Matsuzaki G, Chen Q, Iwamoto Y, Nomoto K. Reevaluation of the origin of CD44high "memory phenotype" CD8 T cells: comparison between memory CD8 T cells and thymus-independent CD8 T cells. Eur. J. Immunol. 2001;31(6):1917-1926. [PubMed]...
F5 TCR transgenic mice challenged in vivo with peptide generate long-lived primed CD8 T cells that hyper-proliferate in response to peptide in vitro. These primed CD8 T cells can be subdivided into three distinct populations on the basis of CD44 cell surface expression. In this report, we show...
Effector CD8+ T cells (CD8 TE) play a key role during hepatotropic viral infections. Here we used advanced imaging in mouse models of hepatitis B virus (HBV) pathogenesis to understand the mechanisms whereby these cells home to the liver... L Guidotti,D Inverso,L Sironi,... - 《Cell》...
CD8 T cells play a central role in antitumor immune responses that kill cancer cells directly. In aged individuals, CD8 T cell immunity is strongly suppressed, which is associated with cancer and other age-related diseases. The mechanism underlying this age-related decrease in immune function remai...
There are not only tumour cells in the patient’s tumour tissue but also many immune cells infiltrates. By using the TIMER database, we analysed the correlation between the expression of CD44 and 6 kinds of infiltrating immune cells, namely, B cells, CD8+ T cells, CD4+ T cells, macr...
T-bet-dependent regulation of CD8+ T-cell expansion during experimental Trypanosoma cruzi infection. cruzi by promoting the expansion of T. cruzi-specific CD8+ T cells in a T cell-intrinsic manner. They also serve to further illustrate the multifaceted... D Cobb,S Guo,AM Lara,... - 《...
There are not only tumour cells in the patient’s tumour tissue but also many immune cells infiltrates. By using the TIMER database, we analysed the correlation between the expression of CD44 and 6 kinds of infiltrating immune cells, namely, B cells, CD8+ T cells, CD4+ T cells, macr...
Persistent hepatitis B virus (HBV) infection results in chronic liver diseases that may progress to chronic hepatitis, liver cirrhosis, and subsequent hepatocellular carcinoma. Previous studies demonstrated that adaptive immunity, in particular CD8 T cel
Although natural killer T cells (NKT cells) are thought to be generated from CD4CD8(DP) thymocytes, the developmental origin of CD4CD8(DN) NKT cells has remained unclear. In this study, we found the level of NK1.1 expression was highest in DN cells, followed by CD4 and CD8 (SP) and ...
The results showed that under the premise of high expression of CD44, the prognosis of STAD patients was poor when the infiltration of B cells, CD8+ T cells, natural killer T cells and type 1T helper cells was reduced. However, there was no significant correlation between the prognosis of...