阻断PD-1/PD-L1可导致衰竭CD8+ T细胞亚群的功能重新激活,最终控制肿瘤生长。 免疫细胞亚群和整体免疫功能随着年龄的增长而下降,这一众所周知的过程被称为免疫衰老。下文的作者3发现,与老年小鼠相比,年轻小鼠的黑色素瘤具有更高水平的FOXP3阳性调节性T细胞(Tregs)和减少的CD8+效应T细胞亚群。在作者的小鼠黑色素瘤模...
(2001). Reevaluation of the origin of CD44(high) "memory phenotype" CD8 T cells: comparison between memory CD8 T cells and thymus-independent CD8 T cells. European Journal of Immunology, 31(6), 1917-1926.Yamada H, Matsuzaki G, Chen Q, Iwamoto Y, Nomoto K. Reevaluation of the origin ...
推荐其采用的方案是CD3、CD4、CD8、CD45RA、CCR7、CD45RO。当然,大家也可以根据自己的喜好选择增加其它标记,例如CD62L、CD95等。 参考资料: T细胞亚群细分标记 T细胞接受抗原刺激后的五个阶段及其表型 T细胞耗竭四阶段 Flynn, J. K. & Gorry, P. R. Stem memory T cells (TSCM)—their role in cancer a...
Only the CD8+CD44hi memory T-cell subset containing both central and effector memory cells was capable of eradicating the lymphoma cells without inducing GVHD. In contrast, CD4+and CD8+ naive T cells, memory CD44hi CD4+ T cells, naive total T cells, and memory CD44hi total T cells either...
Host-reactive CD8+ memory stem cells in graft-versus-host disease. The postmitotic CD44loCD62LhiCD8+ T cells persist throughout the course of GVHD, are generated in the initial phase in response to alloantigens and ... Yi,Zhang,Joe,... - 《Nature Medicine》 被引量: 0发表: 2005年 ...
CD4 and CD8 T-Cell Lineage Gamma-Delta T cells Stem Cells and Development T Follicular Helper Cell Pathway TH1 Pathway (Cellular Immune Response) TH2 Pathway (Humoral Immune Response) Pages Quality Control Multicolor Staining Guide Fluorescence Spectra Analyzer CD Molecule Chart Fluoroph...
CD44hiCD8+ T cells express T-cell activation markers but are defective in GVHD induction in MHC-matched miHA-mismatched B6 recipient mice, whereas CD44loCD8+ T cells express the phenotypes of naive T cells and are extremely potent inducers of GVHD. Interestingly, CD44hiCD8+ T cells themselves...
CD4 and CD8 T-Cell Lineage Gamma-Delta T cells Stem Cells and Development T Follicular Helper Cell Pathway TH1 Pathway (Cellular Immune Response) TH2 Pathway (Humoral Immune Response) Pages Quality Control Multicolor Staining Guide Fluorescence Spectra Analyzer CD Molecule Chart Fluoroph...
CD8BCD8 beta protein, recombinant MRC1MRC1/CD206 protein, recombinant CXCR5CXCR5 protein, recombinant CD276B7-H3 protein, recombinant MS4A1CD20 protein, recombinant Proteoglycans 官方名通用名 SRGNSerglycin/SRGN protein, recombinant TGFBR3TGF-beta RIII/TGFBR3 protein, recombinant ...
CD44的表達是一個指示標記效應記憶T細胞(effector-memory T-cells)。記憶細胞增殖(活化)也可在體外用CFSE(Carboxyfluorescein succinimidyl ester)化學標記進行檢測。 此外,不同的CD44被發現為可以用於某些乳腺癌(breast cancer)和前列腺癌(prostate cancer)幹細胞的細胞表面標記。在乳腺癌研究CD44 + / CD24-表達的有無...