在小鼠中使用CD44、CD62L和CCR7等标记物来识别初始(Tn)、中央记忆(Tcm)和效应记忆(Tem)/效应(Teff)亚群,以及KLRG1和CD127,用于识别记忆前体效应细胞(MPEC)和短寿命效应细胞(SLEC)亚群。见下图,SPF 3个月大和18个月大的C57BL/6J小鼠的脾细胞,分别分析Tn、...
根据表型,功能及转录因子,目前CD8+T细胞可以进一步分为以下不同的亚群: Tnaive CD44-CD62+ T SCM :干细胞记忆T细胞(Stem cell memory T cell) T EM:效应记忆T细胞(Effector memory T Cell):CD44+CD62L- T CM:中枢记忆T细胞(Central memory T Cell):CD44+CD62L+ T pm:外周记忆T细胞(Peripheral Memory T ...
在健康小鼠的外周血液中,首先根据它们的物理参数(FSC和SSC),然后根据CD45、CD3、CD4和CD8标记的表达,识别出四个T淋巴细胞亚群,即TH CD4+(62.8%)、TC CD8+(34.53%)、DN(2.56%)和双阳性(DP)(0.12%)。基于表达CD44和CD62L区分效应细胞和记忆细胞。初始T细胞表现...
同样,CD8+ T细胞中也包括了Tc1、Tc2、Tc17和TcReg等群体。分析设门见下图: 分化和记忆状态 T 细胞分析的一个重要方面是明确它们的分化和记忆状态。利用 CD44 和 CD62L 表达,可以区分循环外周血内的初始、效应和记忆T细胞。初始T细胞为CD62Lhi CD44neg/lo,效应记忆细胞为CD62Lneg/loCD44hi,中央记忆细胞表现出...
老化的幼稚CD8+ T细胞在T细胞激活时产生CD44low、CD62Llow细胞的能力较弱; CD44low、CD62Llow细胞代表早期激活的过渡状态,需要1-碳代谢才能获得效应T细胞表型。衰老CD8+T细胞的活化与1-碳代谢相关基因(比如shmt2)的减少有关。值得注意的是,用1-碳代谢产物(包括甲酸盐和甘氨酸)激活衰老的幼稚T细胞部分挽救了衰老...
CD154 BLOCKADE IMPAIRS GENERATION OF CD8+ CD44HIGH/CD62LLOW/- EFFECTOR/MEMORY T-CELLS INDUCED BY BOTH ALLOANTIGEN EXPOSURE AND LYMPHOPENIA AND RESULTS IN PREVENTION OF SENSITIZATION: 454.An abstract is unavailable. This article is available as a PDF only.doi:10.1097/01.tp.0000332269.41...
We found inefficient generation of CD44 low CD62L low CD8 T cell subset (P4) in draining lymph nodes of tumor-bearing aged mice. In vitro stimulation of naive CD8 T cells first generated P4 cells, followed by effector/memory T cells. The P4 cells contained a unique set of genes related...
The postmitotic CD44loCD62LhiCD8+ T cells persist throughout the course of GVHD, are generated in the initial phase in response to alloantigens and ... Yi,Zhang,Joe,... - 《Nature Medicine》 被引量: 0发表: 2005年 Dendritic cell-activated CD44hiCD8+ T cells are defective in mediating...
Of note, highly proliferative CD8+ T cells expressed high levels of CD44 (CD44hi) but low to moderate levels of CD25, CD69, and CD122 (CD25lo/modCD69lo/modCD122lo/mod; Figure 1C upper row). Most of these CD44hiCD8+ T cells were CD44hiCD62Llo (78%) and some were CD44hiCD62...
CD44 CD44 molecule (Indian blood group) PDB rendering based on 1poz. Available structures: 1poz, 1uuh, 2i83 Identifiers Symbol(s) CD44; CDW44; CSPG8; ECMR-III;