采用CD44-cd19-cd4-AIM2多色免疫组化染色,探讨CD44和AIM2在健康人扁桃体中的分布。有趣的是,CD44在人扁桃体滤泡外(EF)区域的表达明显高于生发中心(GC)。与GC相比,EF区CD4+ T和CD19+ B细胞的CD44表达也显著升高,而GC区域CD4+ T细胞上的CD44表达高于CD19+ B细胞上的CD44表达,表明CD44与EF区域的B细胞相关。G...
CD44是一种复杂的跨膜粘附糖蛋白,表达于人的多种细胞,包括胚胎干细胞、分化细胞和癌细胞。转录过程中不同的选择性剪接,产生CD44的两种亚型,包括标准亚型(CD44s)和CD44变异亚型(CD44v)。CD44是公认的肿瘤干细胞的标志物,是上皮细胞间充质转化(EMT)关键调节因子,参与肿瘤的发生,进展和转移。 CD44基因结构(文献1)...
衰老的幼稚CD4+T细胞导致胞外酸化率(ECAR,一种能量代谢指标)减弱,糖酵解和戊糖-磷酸途径中相关的代谢物减少。但是在衰老过程中,幼稚CD8+T细胞的糖酵解是否也会受损尚不清楚。CD4+T细胞中糖酵解的减少可能是由TCR信号阈值的变化(年龄相关的)引起的。CD4+T细胞中Mir-181a的下调可能有助于降低TCR敏感性。Mir-181a...
T cell receptor-mediated activation of CD4+CD44hi T cells bypasses Bcl10: an implication of differential NF-kappaB dependence of na?ve and memory T cells during T cell receptor-mediated responses. Zeng Hu,Chen Yuhong,Yu Mei,Xue Liquan,Gao Xiang,Morris Stephan W,Wang Demin,Wen Renren. ...
[0108]在又一实施方案中,T细胞表面抗原可选自CD3、CD2、CD4、CD5、CD6、CD8、CD28、 CD40L、CD44、KI2L4、NKG2E、NKG2D、NKG2F、BTNL3、CD186、BTNL8、PD‑1、CD195和NKG2C。或者,T 细胞表面抗原是CD3。 [0109]在另一个实施方案中,TAA可选自B细胞成熟抗原(BCMA)、CD123、GPRC5D、CD33、 15 15 CN11...
【关键词】溃疡性结肠炎;清肠栓;葡聚糖硫酸钠;CD44;CD62L;T淋巴细胞;小鼠 【中图分类号】 R285.5 【文献标志码】 A 【文章编号】 1007—1334(2014)05—0104—05 Efectof“QingchangSuppository”onexpressionofCD44andCD62LinsplenicCD4 T—cellsin
CD4+ T cellsThe lacuna in the knowledge of immunobiology, especially in visceral infections that are fatal if left untreated, are a major hurdle in getting a vaccine candidate for leishmaniasis. Till date, only a few drugs are available to combat human leishmaniasis and a vaccine candidate ...
[关键词] 表面标记物;小鼠;淋巴细胞Changes of cell surfa c e markers CD3,CD4,CD44,CD62L on mouse spleen lym-phoc y t e s a f ter cu l tur e in vitroLI Yan-Chun,ZHAO Li-Na,ZHANG Xian-Yu,QIAO Hong-Mei畅Pediatric Respiratory Department,the First Hospital ofJilin University,Changchun ...
Age-associated parallel increase of Foxp3+CD4+ regulatory and CD44+CD4+ memory T cells in SJL/J mice Effector/memory T cells (Tem) are required to maintain successful immunity, while regulatory T cells (Treg) are required to prevent excessive/uncontrolled ... GM Han,B Zhao,S Jeyaseelan,....
抗体类型: 单抗 同型对照: IgG1 免疫原性: 用法: Description: Specifically recognizes an epitope encoded by exon v6 on the variant portion of human CD44. Standard CD44 (CD44s) lacks the entire variable region and is found mainly in cells of lymphohematopoietic origin. The multiple isoforms (desig...