The cognate interaction between CD40L on T cells and CD40 on antigen-stimulated B cells, macrophage, and dendritic cells is critical for the development of a comprehensive immune response. The non-X-linked form of HIM syndrome is heterogeneous and appears in some cases to be a consequence of ...
The cognate interaction between CD40L on T cells and CD40 on antigen-stimulated B cells, macrophage, and dendritic cells is critical for the development of a comprehensive immune response. The non-X-linked form of HIM syndrome is heterogeneous and appears in some cases to be a consequence of ...
CD40.CD40LinteractiononHUVECs expression ofnotricoxide(NO)and intercellularadhesion molecule.1(ICAM。1 1wereobserved byCO-incubating HUVECswiththemacrophagesofhuman.theeelltypethanhasbeendemonstrated to express CD40Linatherosclerotic plaque.Byexploring ...
Costimulation through CD28 enhances T cell-dependent B cell activation via CD40-CD40L interaction. Changes in T cell helper function were analyzed when anti-CD3-activated T cells were costimulated with mAbs to the CD28 receptor (anti-CD28). T cell-depend... SJ Klaus,LM Pinchuk,HD Ochs,......
Rossi et al., Long-term induction of immuno tolerance after blockage of CD40-CD40L interaction in a mouse model of hemophilia A. Blood. 97: 2750-7 (2001).Rossi G, Sarkar J, Scandella D. Long-term induction of immune tol- erance after blockade of CD40-CD40L interaction in a mouse ...
Inhibition of the CD40/CD40L immunomodulator interaction significantly reduced communication between immune and/or endothelial cells and the development of pulmonary edema. Hence, our results indicate that targeting of the CD40/CD40L interaction could be an important method to prevent TRALI. While ...
The role of CD40/CD40L interaction in cytokine modulation is well documented in the peripheral nervous system and in Alzheimer's disease (AD). We have previously shown that interrupting the CD40/CD40L interaction either pharmacologically or genetically resulted in the mitigation of amyloid precursor pro...
Because interaction of CD154 and CD40 has a key role in initiating alloimmune response and graft survival, subsequent to CD28, CD154-CD40 interactions are perhaps the most well-studied pathway in transplantation. Inhibition of CD154-CD40 interactions diminishes innate immune responses to transplanted ...
Objective: To investigate the effect of interruption of CD40-CD40L interaction on the atherosclerotic plaque in ApoE(superscript -/-) mice. Methods: Carotid atherosclerotic lesions model was rapidly induced by perivascular collar placement in ApoE(superscript -/-). The ApoE(superscript -/-) mice wer...
CD40-CD40L interaction also plays important roles in monocyte activation and dendritic cell maturation. 表达系统 : Escherichia coli 溶解方法: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous ...