Jenn-Haung Lai et al,Targeting the CD40-CD154 Signaling Pathway for Treatment of Autoimmune Arthritis,Cells 2019, 8, 927 Robert H. Vonderheide,The Immune Revolution: A Case for Priming, Not Checkpoint,Cancer Cell 33, April 9, 2018 Gregory...
此外,根据具体情况,CD40 连接可以激活“经典”和非经典 NFkB 途径。 Ref(2007)Prospect of Targeting the CD40 Pathway for Cancer Therapy. 五、CD40在免疫系统中的功能 cDC将抗原呈递给CD4+T细胞,增加CD4+T细胞CD40配体CD40L的表达; CD40L-CD40结合在cDC1中触发CD40信号,从而增...
【3】The Role of Soluble CD40L Ligand in Human Carcinogenesis. Anticancer Research,2018, 38: 3199-3201.【4】https://www.bosterbio.com/newsletter-archive/20200212-cd40-signaling-pathway
From previous studies, we can know that the CD40-CD40L pathway has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The TNFR-receptor ...
3.Targeting the CD40-CD40L pathway in autoimmune diseases=Humoral immunity and beyond(2019); 4.Bispecific antibodies increase the therapeutic window of CD40 agonists through selective dendritic cell targeting(2020); 5.CD40 agonist antibodies in cancer immunotherapy(20...
The presence of this sole subset in the absence of IgM+-only and switched CD27+memory B cells suggests that it belongs to a separate diversification pathway.doi:10.1073/pnas.98.3.1166Sandra WellerAhmad FailiCorinne GarciaNational Academy of Sciences...
Lai, Jenn-Haung et al. "Targeting the CD40-CD154 Signaling Pathway for Treatment of Autoimmune Arthritis." Cells 2019, 8, 927. DOI: 10.3390/cells8080927 Dakal, Tikam Chand et al. "Mechanistic basis of co-stimulatory CD40-CD40L ligation mediated regulation of immune responses in cancer and ...
CD40 promotion of amyloid beta production occurs via the NF-kappaB pathway. The CD40 receptor is a member of the tumor necrosis factor (TNF) super-family of trans-membrane receptors. Interaction of CD40 with its ligand CD40L mediat... Ghania Ait〨hezala,Claude〩enry Volmar,J Frieling,... ...
Conclusion CD40 and CD40L pathway may play important roles in the pathogenesis of Persistent ITP,and it is possible to be a good therapeutic target if we can obstruct this way. [Key words] CD40;CD40L;ITP;Children;Persistent;Pathogenesis 免疫性血小板减少症(immune thrombocytopenia,ITP)是儿童时期常见...
Evidence of CD40L/CD40 pathway involvement in experimental transfusion-related acute lung injury Sofiane Tariket, Hind Hamzeh-Cognasse, Sandrine Laradi, Charles-Antoine Arthaud, Marie-Ange Eyraud, Thomas Bourlet, Philippe Berthelot, Olivier Garraud & Fabrice Cognasse Scientific Reports volu...