此外,根据具体情况,CD40 连接可以激活“经典”和非经典 NFkB 途径。 Ref(2007)Prospect of Targeting the CD40 Pathway for Cancer Therapy. 五、CD40在免疫系统中的功能 cDC将抗原呈递给CD4+T细胞,增加CD4+T细胞CD40配体CD40L的表达; CD40L-CD40结合在cDC1中触发CD40信号,从而增...
Jenn-Haung Lai et al,Targeting the CD40-CD154 Signaling Pathway for Treatment of Autoimmune Arthritis,Cells 2019, 8, 927 Robert H. Vonderheide,The Immune Revolution: A Case for Priming, Not Checkpoint,Cancer Cell 33, April 9, 2018 Gregory...
【3】The Role of Soluble CD40L Ligand in Human Carcinogenesis. Anticancer Research,2018, 38: 3199-3201.【4】https://www.bosterbio.com/newsletter-archive/20200212-cd40-signaling-pathway
(CD40L), is a protein that is primarily expressed on activated T cells and is also a member of the TNF superfamily of molecules. From previous studies, we can know that the CD40-CD40L pathway has been found to be essential in mediating a broad variety of immune and inflammatory responses ...
3.Targeting the CD40-CD40L pathway in autoimmune diseases=Humoral immunity and beyond(2019); 4.Bispecific antibodies increase the therapeutic window of CD40 agonists through selective dendritic cell targeting(2020); 5.CD40 agonist antibodies in cancer immunotherapy(20...
From direct targeting of CD40 onto tumor cells to licensing professional antigen presenting cells (APC), and from in vivo activation of immune effectors to enabling adoptive cell immune interventions, this pathway already shows translational promise in oncology and infectious diseases. In light of the...
While early work focused on the essential role of the CD40-CD40L pathway in the generation of humoral immune responses to T-dependent antigens, an abundance of studies has demonstrated that the action of the CD40 axis extends well beyond T-cell/B-cell interactions. This review will highlight ...
Conclusion CD40 and CD40L pathway may play important roles in the pathogenesis of Persistent ITP,and it is possible to be a good therapeutic target if we can obstruct this way. [Key words] CD40;CD40L;ITP;Children;Persistent;Pathogenesis 免疫性血小板减少症(immune thrombocytopenia,ITP)是儿童时期常见...
Increasing evidence suggests a central role for the CD40L-CD40 signaling pathway in several immunogenic and inflammatory processes,including atherosclerosis. It was also found that CD40L-CD40 signaling pathways play an important role in several autoimmu
ofjmmunologica1effectofimmunocompetantcells.TheabnormityofCD40一CD4OLsignalpathwaywil1re. sultinpathologicalimmunoreactions. Indermatologyfield.theinteractionofCD40一CD40LiSinvolvedin theoccurrenceanddevelopmentofimmunologic.inflammmo~infectiousandtumorousdermatoses. ...