The interaction between CD40 and CD40 ligand (CD40L) a crucial co-stimulatory signal for activating adaptive immune cells, has a noteworthy role in atherosclerosis. It is well-known that atherosclerosis is linked to immune inflammation in blood vessels. In atherosclerotic lesions, there is a ...
CD40-Mediated Amplification of Local Immunity by Epithelial Cells Is Impaired by HPV The interaction between the transmembrane glycoprotein surface receptor CD40 expressed by skin epithelial cells (ECs) and its T-cell-expressed ligand CD154... B Tummers,R Goedemans,V Jha,... - 《Journal of Inve...
Methods CD antigens on tumor cells were determined by flow cytometry and expression of HLA-I and HLA -II molecules by ABC immunohistochemical staining. 方法采用FACS检测细胞表面的CD抗原,采用ABC免疫组化染色检测肿瘤细胞HLA-I、II类分子的表达。 3. Method The cytotoxicity of NK was measured by MTT...
This inhibitory effect may be due to the blocking of priming self-antigen-specific T cells, the inhibition of the effector function of CD40L such as the activation of CD40-positive cells, and/or the blocking of the humoral response. In addition to its well-characterized receptor, CD40, there ...
However, more than a decade of research has shown that the receptors for TNFSFs on responding cells require clustering in order to signal. Thus, single trimers are poor stimuli because they cannot produce the necessary clustering. Likewise, studies of agonist anti-TNFSF receptor antibodies (anti...
Apoptotic cells were found in all cases examined, and their frequency increased significantly during acute rejection (0.17 vs. 9.0; P<0.05), The immunoreactivity of Fas and Fast antigen was higher in specimens with acute rejection than in those with stable graft function. Increased apoptosis...
On cells lacking CD40L, this fusion protein is poorly active with respect to CD95 activation [median effective dose (ED50)>1 microg/ml], but it stimulates CD95 signaling with high efficiency upon binding to membrane-expressed CD40L (ED50<1 ng/ml). Thus, cell surface immobilization mediated...
CD40L- containing virus-like particle as a candidate HIV-1 vaccine targeting dendritic cells. J. Acquir. Immune Defic. Syndr. 56: 393-400.Franco, D.; Liu, W.; Gardiner, D.F.; Hahn, B.H.; Ho, D.D. CD40L-containing virus-like particle as a candidate HIV-1 vaccine targeting ...
Background: Memory T cells (Tms) form a barrier against long-term allograft survival; however, CD4(+)Foxp3(+) regulatory T cells (Tregs) can suppress allograft rejection. The OX40/OX40L pathway is critical to the generation of Tms and turns off Treg suppressor function.Dai, HelongPeng, ...
231.5: Anti-CD40L Antibody Promotes the Differentiation of Vy2+ Regulatory Gamma-delta T Cells and Prolongs the Survival of Skin Allograftsdoi:10.1097/01.tp.0000885636.53964.84Shilpi GiriH. T. MeiteiA. MishraG. LalTransplantation