IgA, and IgE with normal or elevated levels of IgM. This disorder can be acquired or familial with either X-linked or autosomal patterns of inheritance. The X-linked form of the disease is a consequence of mutations in the CD40 ligand (CD40L) gene that encodes a protein expressed primarily...
CD40L interaction with CD40 is required for normal cellular immune responses such as T cell-mediated activation of monocytes/macrophages, proinflammatory cytokine production, and leukocyte extravasation. We investigated the role of CD40/CD40 ligand (L) interactions during disseminated candidiasis in CD40L ...
CD40L interaction, (b) cytokine-mediated protection by CD4+ T cells primed by vesicular stomatitis virus against a challenge infection with recombinant vaccinia virus expressing the glycoprotein of vesicular stomatitis virus was found to be equivalent in CD40L-deficient and normal mice. Thus, CD40-...
The cognate interaction between CD40L on T cells and CD40 on antigen-stimulated B cells, macrophage, and dendritic cells is critical for the development of a comprehensive immune response. The non-X-linked form of HIM syndrome is heterogeneous and appears in some cases to be a consequence of ...
Inhibition of the CD40–CD40L interaction in humans as a result of a mutant CD40L causes the X-linked hyper IgM syndrome, a severe immunodeficiency characterized by the absence of serum IgG, IgA, and IgE (Callard, Armitage, Fanslow, & Spriggs, 1993) due to the inability of B cells to ...
CD40.CD40LinteractiononHUVECs expression ofnotricoxide(NO)and intercellularadhesion molecule.1(ICAM。1 1wereobserved byCO-incubating HUVECswiththemacrophagesofhuman.theeelltypethanhasbeendemonstrated to express CD40Linatherosclerotic plaque.Byexploring ...
Costimulation through CD28 enhances T cell-dependent B cell activation via CD40-CD40L interaction. Changes in T cell helper function were analyzed when anti-CD3-activated T cells were costimulated with mAbs to the CD28 receptor (anti-CD28). T cell-depend... SJ Klaus,LM Pinchuk,HD Ochs,......
Description: CD40 ligand, (CD40L, also known as CD154, TRAP or gp39) is a membrane glycoprotein expressed on activated CD4+ T-cells, NK cells, mast cells, basophils and eosinophils. The CD40-CD40L interaction stimulates B cell immune response which includes cell surface antigen expression, cell...
The role of CD40/CD40L interaction in cytokine modulation is well documented in the peripheral nervous system and in Alzheimer's disease (AD). We have previously shown that interrupting the CD40/CD40L interaction either pharmacologically or genetically resulted in the mitigation of amyloid precursor pro...
In accordance with what has been previously suggested, that is, that interaction of CD40L with CD40 can cause apoptosis of tumor cells,11 we have observed an advantage of the armed virus in CD40 þ tumor cell line in vivo. Gene Therapy (2014) 195 – 204 & 2014 Macmillan Publishers ...