EB病毒(EBV)编码的癌基因LMP1可使病毒在免疫系统的细胞中长期存活,并为EBV介导的人静止B细胞永生化过程所必需.它通过接头蛋白肿瘤坏死因子(TNF)受体相关因子(TRAFs)和TNF受体相关死亡结构域蛋白(TRADD),激活NF-κB,丝裂原活化蛋白激酶(MAPK)和JAK/STAT等信号途径,上调B细胞上粘附分子LFA-1,ICAM-1和共刺激分...
The Epstein-Barr virus-encoded transforming protein latent membrane protein 1 (LMP1) serves as a functional mimic of CD40 signals to B cells but lacks key regulatory controls that restrain CD40 signaling. This allows LMP1 to activate B cells in an abnormal manner that can contribute to the ...
推测,CD40分子和LMP1类似可能也存在自身活化的 现象,导致细胞的恶性增殖。 CD40分子突变体在肿瘤细胞上的表达也日益受 到重视。已有文献报道。多发性骨髓瘤RPMI8226细 胞上CD40分子第三结构域氨基酸存在突变(TCA一 1’rA,Ser.Leu),推测CD40分子突变体和配体亲和力发 ...
Our aim was to experimentally address the role of immune suppression in the transformation of an indolent B-cell lymphoma. Among the very few mouse models of indolent lymphoma, latent membrane protein 1 (LMP1)/CD40 chimeric protein-expressing mice (LMP1/CD40-expressing mice) are characterized by ...
The Epstein-Barr virus (EBV)-encoded protein latent membrane protein 1 (LMP1) is essential for EBV-mediated B cell transformation and plays a critical role in the development of post-transplant B cell lymphomas. LMP1 also contributes to the exacerbation of autoimmune diseases such as systemic lupu...
The Epstein-Barr virus (EBV)-encoded protein latent membrane protein 1 (LMP1) is essential for EBV-mediated B cell transformation and plays a critical role in the development of post-transplant B cell lymphomas. LMP1 also contributes to the exacerbation of autoimmune diseases such as systemic lupu...
DCs in DC-LMP1/CD40 mice have continuous CD40-signalling. Although the above experiments suggest that CD40-signalling causes DCs to leave the LP, we could not exclude an influence of inflammatory stimuli, which have been previously reported to augment effects of CD40-ligation on DCs23,24,30. ...
CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr Virus-encoded LMP1: involvement of TRAF3 as a common mediator. Oncogene 1996; 13: 2243–2254. 10 Tong AW, Papayoti MH, Netto G, Armstrong DT, Ordonez G, Lawson JM et al. Growth-inhibitory effects of CD40 ...
CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr Virus-encoded LMP1: involvement of TRAF3 as a common mediator. Oncogene 1996; 13: 2243–2254. CAS PubMed Google Scholar Altenburg A, Baldus SE, Smola H, Pfister H, Hess S . CD40 ligand-CD40 interaction ...
1. Figure 1 a 100 75 b Ctr 50 25 0 0 Control DC-LMP1/CD40 DC-LMP1/CD40 with ABX DC-LMP1/CD40 x Rag1–/– 5 10 15 Age (weeks) 20 c 800 600 * 400 DC-LMP1/CD40 Ctr DC-LMP1/CD40 200 0 No ABX +ABX Rag1–/– This work is licensed under a Creative Commons Attribution 4.0...