CD40配体（CD40L）是一种重要的免疫调节分子，也称为CD154、gp39、肿瘤坏死因子相关激活蛋白(TNF associated activation protein, TRAP)或T细胞-B细胞活化分子(T cell-B cell-activating molecule, T-BAM)CD40L是一种主要在活化的T细胞上表达的蛋白质，是TNF超家族分子的一员。它与抗原呈递细胞（APC）上的CD40（...
CD40 ligation in B cell acti- vation, isotype switching and memory development. Semin Immunol 1994; 6:303-10.Gray, D., Siepmann, K., Wohlleben, G. (1994) CD40 ligation in B cell activation, isotype switching and memory development. Semin. Immunol. 6, 303-310....
作为肿瘤坏死因子 (TNF) 受体超家族的成员,CD40 由 DC、骨髓细胞和 B 细胞等表达,其中连接导致细胞活化,由主要在 CD4 +辅助 T 细胞上表达的 CD40 配体 (CD40L) 激活。 Ref: (2020 PNAS)Sufficiency of CD40 activation and immune checkpointblockade for T cell priming an...
in vivo CD40 activation Erickson, J. J., et al. (2014). “Programmed death-1 impairs secondary effector lung CD8(+) T cells during respiratory virus reinfection.” J Immunol 193(10): 5108-5117 in vitro B cell stimulation/activation Muppidi, J. R., et al. (2014). “Loss of signalli...
体外B细胞刺激/激活(in vitro B cell stimulation/activation) 1. Xu, H., et al. (2015). 'Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8' Nat Immunol .2. Muppidi, J. R., et al. (2014). 'Loss of signalling via Galpha13 ...
performed a genome-wide CRISPR/Cas9 screen to reveal key B cell factors that control CD40 abundance and that regulate CD40 responses. Keywords: B cell activation, NF-kappaB, MAP kinase, CRISPR screen, TNF receptor superfamily, humoral immunity, immunodeficiency, N6-Methyladenosine, ESCRT, germinal ...
in vivo CD40 activation Bartkowiak, T., et al. (2015). “Unique potential of 4-1BB agonist antibody to promote durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine.” Proc Natl Acad Sci U S A 112(38): E5290-5299. in vitro B cell stimulation/activation Xu,...
[15] Eliopoulos AG, Davies C, Knox PG, Gallagher NJ, Afford SC, Adams DH, Young LS. CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily. Mol. Cell Biol. 2000 Aug;20(15):5503-15. PubMed ID: 10891490 ...
摘译自:Diggs LP, Ruf B, Ma C, Heinrich B, et al. CD40-mediated immune cell activation enhances response to anti-PD1 in murine intrahepatic cholangiocarcinoma[J]. J Hepatol, 2020. 吉林大学第一医院感染病中心肝病科 盛...
in vivo CD40 activation Bartkowiak, T., et al. (2015). “Unique potential of 4-1BB agonist antibody to promote durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine.” Proc Natl Acad Sci U S A 112(38): E5290-5299. in vitro B cell stimulation/activation Xu,...