本研究还揭示了一种新的机制,在这种机制中,α-CD38抗体可能是治疗由bcr信号异常驱动的B细胞恶性肿瘤的有价值的选择。 论文ID 题目:Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B cells...
2. Provan D, Arnold DM, Bussel JB, et al. Updated international consensus report on the investigation and management of primary immune thrombocytopenia. Blood Adv. 3, 3780-3817 (2019).3. Mahévas M, Patin P, Huetz F, et al. B cell depletion in immune thrombocytopenia reveals splenic long...
primary systemic amyloidosis、套细胞淋巴瘤MCL、急性髓系白血病AML、急性淋系白血病ALL、NKcell leukemia、NK/T-cell lymphoma (NKTCL)等肿瘤细胞中均有较高的表达,但CD38表达最高的当属多发性骨髓瘤(multiple myeloma,MM),临床研究中发现,CD38的表达水平治疗效果负相关,这使得CD38成为多发性骨髓瘤靶向治疗的良好...
梁洋教授:未来针对MM的耐药性研究应该更加关注骨髓免疫微环境对肿瘤耐药的影响。目前CAR-T细胞疗法已经在复发难治性MM的治疗中起到了显著的疗效,其中又以抗BCMA CAR-T最为成功。未来可以继续期待其他替代靶点,以及双靶点CAR-T治疗的问世...
多发性骨髓瘤(Multiple Myeloma, MM)是一种浆细胞(plasma cell, PC)恶性增殖性疾病,其特征是骨髓中浆细胞像肿瘤细胞一样无限制的增殖。正常浆细胞是B淋巴细胞在抗原刺激下分化形成的可以合成和分泌各类抗体的免疫细胞,在机体与病毒、病毒感染作斗争时发挥重要的作用。MM中浆细胞癌变迅速增殖,可能会排挤骨髓中的正常造...
CD38 expression distinguishes two groups of B-cell chronic lymphocytic leukemias with different responses to anti-IgM antibodies and propensity to apoptosis. Blood. 1996; 88:1365-1374.Zupo S, Isnardi L, Megna M, et al. CD38 expression distinguishes two groups of B-cell chronic lymphocytic ...
本研究针对这一问题,探讨CD38基因敲除对小鼠脾脏B细胞发育的影响,现报道如下:1 资料与方法 1.1 一般资料 小鼠CD38基因敲除,克隆外显子1号到6号,在129S系14天小鼠胚胎干细胞中转染CLa线性敲除载体,根据2/300的比例对双阳性克隆进行挑选,并确定正确打靶克隆。在C57BL/6j小鼠的囊胚里注入CD38-/-的胚胎干细胞,并...
Pre-pro-B, pro-B, pre-B, and immature B cells from murine bone marrow all stained positive for CD38. Interestingly, CD38 expression increases with B cell maturation. To assess the role of CD38 during B cell maturation, CD38-deficient mice were analyzed. CD38-/- mice showed a significant ...
► Human regulatory B (Breg) cells are enriched within a CD19 +CD24 hiCD38 hi subset ► Human CD19 +CD24 hiCD38 hi Breg cells suppress T helper 1 cell differentiation in vitro ► Human Breg cell-suppressive function depends on expression of IL-10, CD80, and CD86 ► Breg cells ...
Cui Q, Qian C, Xu N, Kang L, Dai H, Cui W, Song B, Yin J, Li Z, Zhu X, Qu C, Liu T, Shen W, Zhu M, Yu L, Wu D, Tang X. CD38-directed CAR-T cell therapy: a novel immunotherapy strategy for relapsed acute myeloid leu...