Notably, the proportion of CD38+IgD+ was significantly and positively correlated with the serum IgG level among pSS patients (R2=0.5723). These results raise the possibility that increased serum IgG level in pSS patients was attributed to an increase in the population of this activated B cell ...
骨髓活检示:浆样细胞数量增加(约70%),Kappa阳性,Lambda阴性,CD20阴性,CD38和CD138阳性,考虑浆样细胞增生性肿瘤,不能排除浆样细胞白血病的可能,请结合临床及遗传学检查。 免疫组化:MPO、CD15粒系(+),E-cad红系(+),CD42b巨核系(+)、CD3(T细胞+)、CD20(个别...
Normal IgM(-)IgD(+) CD38(+) B cells and IgM(-)IgD(+) multiple myelomas (MM) are characterized by Cmu deletion, biased Iglambda expression and hypermutated IgV regions. The predominant Iglambda usage has been proposed as resulting from secondary Ig gene rearrangements during extensive clonal ...
We have identified and isolated a subpopulation of IgD+ B cells (IgD+CD38+ B cells) from human tonsils which expresses the germinal center (GC)-associated surface markers CD10, CD38, CD75, CD77 and Cd95/Fas. The heterogeneity of expression of several markers on IgD+ CD38+ B cells sugges...
抗免疫球蛋白D抗体(anti-immunoglobulin D antibody,抗IgD抗体)一直以来主要作为工具药来研究正常B细胞上的膜结合型IgD(membrane IgD,m IgD).最新研究表明,在病理状态下,抗IgD抗体可以通过选择性清除成熟B细胞,降低自身抗体的水平,抑制B细胞上B细胞活化因子(B cell activating factor belonging to the TNF family,BAF...
a Flow panel of B cell subsets in the PBL (left) and in NP (right): naïve or IgD+ B cell: CD19+IgD+CD27−, CD27+ memory B cell (CD27+M): CD19+IgD−CD27+CD38−, and antibody secreting cells (ASC): CD19+IgD−CD27+CD38++. b Frequency of B cell subsets (Naïve...
Plasmodium falciparum infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell s
B cellGerminal centerIgDWe have identified and isolated a subpopulation of IgD+ B cells (IgD+ CD38+ B cells) from human tonsils which expresses the germinal center (GC)-associated surface markers CD10, CD38, CD75, CD77 and CD95/Fas. The heterogeneity of expression of several markers on ...
We have identified and isolated a subpopulation of IgD<SUP>+</SUP> B cells (IgD<SUP>+</SUP> CD38<SUP>+</SUP> B cells) from human tonsils which expresses the germinal center (GC)-associated surface markers CD10, CD38, CD75, CD77 and CD95/Fas. The heterogeneity of expression of seve...
The role of immune cell signatures in the pathogenesis of ovarian-related diseases: a causal inference based on Mendelian randomization were associated with benign ovarian tumors; and three immune phenotypes, including BAFF-R on IgD- CD38+ B cells, were associated with malignant ovarian tu... YM...