Comprehensive analyses of the phenotype, function, and transcriptome of the CD27-CD38+B cell subset is conducted compared with memory and naive B cells. We find that the CD27-CD38+B cells exhibit a transitional B cell phenotype and an extremely high turnover rate. Importantly, individuals with...
·论著·CD19、CD27 和 CD38 标记的 B 淋巴细胞亚群在系统性红斑狼疮外周血中的分布及临床意义张智贤 1 ,何秋莹 2 ,鲍蕴文 1 ,丁睿 1 ,曾华 11. 中山大学孙逸仙纪念医院检验科,广东 广州 510120;2. 中山大学附属第一医院检验科,广东 广州 510080摘要:目的 研究系统性红斑狼疮(SLE)患者外周血中 B 淋巴...
8. Gambles, M.T., et al., Crosslinking of CD38 Receptors Triggers Apoptosis of Malignant B Cells. Molecules, 2021. 26(15). 9. Overdijk, M.B., et al., The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Ce...
Compared with healthy subjevts, the mean fluorescence intensities (MFIs) of CD19 and the percentages of memory B cells in peripheral blood of the patients with RA were significantly decreased, while the percenta ges of naive B cells were increased (P<0.05).The percentages of plasmablasts in ...
3. Wo YJ, Gan ASP, Lim X, et al. The Roles of CD38 and CD157 in the Solid Tumor Microenvironment and Cancer Immunotherapy. Cells. 2019;9(1):26. 4. Covarrubias, A.J., Kale, A., Perrone, R. et al. Senescent cells promote tissue...
Wo Y J, Gan A S P, Lim X, et al. The Roles of CD38 and CD157 in the Solid Tumor Microenvironment and Cancer Immunotherapy[J]. Cells, 2020, 9(1): 26. Hogan K A, Chini C, Chini E N. The multi-faceted ecto-enzyme CD38: roles in immunomodulation, cancer, aging and metabolic di...
西安杨森医学事务部负责人李滨介绍：“作为国内首个获批的针对多发性骨髓瘤的CD-38单克隆抗体靶向药物，兆珂®的显著疗效和安全性已在国际和国内临床试验中得到充分证实，为国内复发难治性多发性骨髓瘤患者提供了一项拥有全新作用机制的、安全有效的治疗选择。”两项国际临床研究汇总分析结果显示，既往接受过多线治疗的...
与大部分肿瘤不同,CD38的表达通常局限于肿瘤浸润免疫细胞(tumor infiltrating immune cells, TIICs),在上皮细胞很少表达,且CD38+ TIIC密度随着mCRPC的进展而增加,并与较差的总生存率独立相关,因此支持CD38在TIICs上的表达作为一种潜在的预后生物标志物[39]。
B,T,and NK cells, monocyte/macrophages 5 Rat CD 38 34.4 TM 76 Spleen, liver, heart, thymus ileum, colon, salivary glands, pancreatic islet cells ? TM, transmembrane CD38除了锚钉在细胞膜上外(45kDa, mCD38),还以可溶性的形式存在(39kDa, sCD38),可能为细胞膜蛋白被剪切的结果。因此,在体外培养...
西安杨森医学事务部负责人李滨介绍:“作为国内首个获批的针对多发性骨髓瘤的CD-38单克隆抗体靶向药物,兆珂®的显著疗效和安全性已在国际和国内临床试验中得到充分证实,为国内复发难治性多发性骨髓瘤患者提供了一项拥有全新作用机制的、安全有效的治疗选择。” ...