本研究还揭示了一种新的机制,在这种机制中,α-CD38抗体可能是治疗由bcr信号异常驱动的B细胞恶性肿瘤的有价值的选择。 论文ID 题目:Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B cells...
CD38是一种具有外酶活性的跨膜糖蛋白,也具有受体和黏附分子的功能。CD38在正常的淋巴细胞、髓系细胞及非造血组织细胞中,CD38分子表达水平较低,但在MM细胞中CD38高水平表达,因此CD38分子是MM治疗的理想靶点。 CD38分布 在多发性骨髓瘤(MM)细胞上高表达,对肿瘤的发生、发展起调控作用。除此之外,CD38在B细胞、巨噬细...
primary systemic amyloidosis、套细胞淋巴瘤MCL、急性髓系白血病AML、急性淋系白血病ALL、NKcell leukemia、NK/T-cell lymphoma(NKTCL)等肿瘤细胞中均有较高的表达,但CD38表达最高的当属多发性骨髓瘤(multiple myeloma,MM),临床研究中发现,CD38的表达水平治疗效果负相关,这使得CD38成为多发性骨髓瘤靶向治疗的良好...
CD38, a surface protein whose expression increases upon normal B-cell activation, is a marker of disease aggression in B-cell chronic lymphocytic leukemia (B-CLL). Higher percentages of CD38-expressing CLL B cells may be found in lymphoid compartments compared to peripheral blood. Therefore, it ...
针对复发或难治性MM中B细胞成熟抗原(B-cell maturation antigen, BCMA)和CD38的双特异性CAR-T细胞疗法也获得了长足的发展。靶向BCMA和CD38的人源化双特异性CAR-T细胞治疗在患者中被证明是可行、安全和显著有效的,并表现出明显的体内持久性、深度和反应能力[35,36]。然而,CD38 CAR-T治疗急性髓细胞白血病患者在异...
3. Mahévas M, Patin P, Huetz F, et al. B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells. J Clin Invest. 123, 432-442 (2013).转载自: https://open.work.weixin.qq.com/wwopen/mpnews?mixuin=jld-BgAABwAcUCs1AAAUAA&mfid=WW0320--EwFYQAABwCcsu8Q2NKc...
2024年2月2日,浙江大学医学院附属第一医院黄河教授与浙江大学基础医学院钱鹏旭研究员及浙江大学医学院附属第一医院胡永仙主任医师团队合作,在 Cell Reports Medicine 期刊发表了题为:Inhibition of CD38 enzymatic activity enhances CAR-T cell immun...
基于Jonathan Fromm等人前期在流式细胞术诊断经典霍奇金淋巴瘤的工作基础,Sindhu Cherian和Jonathan Fromm进一步使用流式细胞术诊断能力,使其扩大到了原发性纵隔大B细胞淋巴瘤(PMLBCL)。 PMLBCL是与典型霍奇金淋巴瘤免疫表型相似的B细胞非霍奇金淋巴瘤。在这篇题为《Evaluation of Primary Mediastinal Large B Cell Ly...
Germinal center formation is the result of antigenic stimulation of B cells in a T cell-rich area. B cells cycle through the germinal centers, and a small percentage survive to become plasma cells or memory B cells. The transformation from a mature B cell into a germinal center B cell and...
3. Mahévas M, Patin P, Huetz F, et al. B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells. J Clin Invest. 123, 432-442 (2013). 转载自: https://open.work.weixin.qq.com/wwopen/mpnews?mixuin=jld-BgAABwAcUCs1AAAUAA&mfid=WW0320--EwFYQAABwCcsu8Q2...