These results are in contrast to studies of human CD38 where high expression of CD38 is a marker for GC B cells. In mice, CD38 expression is related to B cell differentiation and in particular the formation of mature isotvoe switched B cells, however it is not, as in humans, expressed ...
In addition, serum B cell-activating factor belonging to the tumor necrosis factor family (BAFF) levels and platelet-associated immune globulin G antibody titers correlated positively with regulatory B cell, pre-GC B cell, and auto-reactive B cell counts. Serum interferon-伪 (IFN-伪) levels ...
除了B细胞成熟抗原(B Cell Maturation Antigen,BCMA,CD269)这一候选抗原外,多发性骨髓瘤细胞广泛表达CD38蛋白。CD38也被称为环状的ADP-核糖水解酶,是一种糖蛋白。CD38分子广泛表达于造血母细胞,在NK细胞、T细胞、B细胞等也有表达。有文献报道,与正常浆细胞相比,骨髓瘤细胞CD38的表达明显增加,使得CD38成为治疗这一癌...
CD38连接后可以令一大部分(约40%)生发中心的B细胞(GC)免于凋亡。若将GC B细胞暴露在抗CD38抗体环境可上调原癌基因bcl2的表达量,与CD40L的效应一致。CD38单克隆抗体的抗凋亡作用效应小于抗CD40抗体或CD40L(Zupo, S., Rugari, E., Dono, M., Tamborelli,G., Malavasi, F., and Ferrarini,M. (1994) ...
经BRDU和7AAD染色后,通过流式细胞术检测CD38+和CD 38-细胞的细胞周期状态。在体外使用CD38 NADase抑制剂(78c)处理CD38+MM细胞株(NCI-H929和KMS-12PE)和来源于MM患者的骨髓细胞,经膜联蛋白V和PI染色后用流式细胞术测定MM细胞活性。采用TQ8050 GC–MS/MS分析...
一段高GC含量区可能是cd38 的启动子区,调节CD38的表达。 CD38是一个45kDa的单链跨膜糖蛋白,整体结构分为N末端短的胞质尾,单次跨膜域和 C端长的胞外区(图1)。其开放阅读框含有300个氨基酸残基,5′UTR比较短小,69bp; 3′UT含R有260bp,不包括PolyA尾。其编码的多肽链分子量为34,288道尔顿。天然的CD38 ...
)。 一段高 GC 含量区可能是 cd38 的启动子区, 调节 CD38 的表达。 CD38 是一个 45kDa 的单链跨膜糖蛋白, 整体结构分为 N 末端短的胞质尾, 单次跨膜域和 C 端长的胞外区 (图 1)。 其开放阅读框含有 300 个氨基酸残基, 5′UTR 比较短小, 69bp;3′UTR 含有 260bp, 不包括 PolyA 尾。 其...
Identification of murine germinal center B cell subsets defined by the expression of surface isotypes and differentiation antigens. and high levels of CD38 consistent with either prolonged recruitment into the GC reaction or protracted expression of these markers during differentiation within... SM Shina...
一段高GC含量区可能是cd38的启动子区,调节CD38的表达。CD38综述CD38是一个定位于膜上的糖蛋白,催化环腺苷二磷酸核糖(cADPR,cyclicADP-ribose)的合成和降解。cADPR是核苷酸的代谢产物,通过作用于ryanodine受体(RyRs)参与细胞内钙库的钙动员。许多研究发现CD38/cADPR介导的Ca2+信号传递和通过RyRs通道的Ca2+释放在Ca2+...
Expression profile of CD10, Bcl-6, CD138, Bcl-2 and MUM1 and their prognostic value in 136 patients with diffuse large B-cell lymphoma Objective We evaluated the value of using a panel of GC B-cell (CD10 and Bcl-6) and activation (MUM1, CD138 and Bcl-2) markers by immunohistoche...