Notably, the proportion of CD38+IgD+ was significantly and positively correlated with the serum IgG level among pSS patients (R2=0.5723). These results raise the possibility that increased serum IgG level in pSS patients was attributed to an increase in the population of this activated B cell ...
骨髓活检示:浆样细胞数量增加(约70%),Kappa阳性,Lambda阴性,CD20阴性,CD38和CD138阳性,考虑浆样细胞增生性肿瘤,不能排除浆样细胞白血病的可能,请结合临床及遗传学检查。 免疫组化:MPO、CD15粒系(+),E-cad红系(+),CD42b巨核系(+)、CD3(T细胞+)、CD20(个别...
Local class-switch recombination has been intimated but B cell precursors and mechanisms remain elusive. Here we describe the dynamics underlying the generation of IgE-antibody secreting cells (ASC) in human nasal polyps (NP), mucosal tissues rich in ASC without germinal centers (GC). Using VH ...
以颞颌关节炎为首发表现的IgD型多发性骨髓瘤 一例 张慧敏 谢丽娜 刘雪乐 赵丹 刘清池 【摘要】多发性骨髓瘤（MM）是一种恶性浆细胞病，以骨痛、肾功能不全、贫血、高钙血症为主要症状，临床表现复杂多样，极易误诊、漏诊。以颞颌关节炎为首发表现的MM少见，该文报道1例以颞颌关节炎为首发表现的IgD型...
- 《Exp Cell Biol》 被引量: 39发表: 1985年 A novel in vitro model of early human adult B lymphopoiesis that allows proliferation of pro-B cells and differentiation to mature B lymphocytes. To develop a model of early human adult B lymphopoiesis, we cultured CD34[SUP+]CD38[SUP+]CD10[...
抗免疫球蛋白D抗体(anti-immunoglobulin D antibody,抗IgD抗体)一直以来主要作为工具药来研究正常B细胞上的膜结合型IgD(membrane IgD,m IgD).最新研究表明,在病理状态下,抗IgD抗体可以通过选择性清除成熟B细胞,降低自身抗体的水平,抑制B细胞上B细胞活化因子(B cell activating factor belonging to the TNF family,BAF...
Absolute CD19<sup>+</sup> B cell counts, including counts of immature (CD10<sup>+</sup> CD38<sup>++</sup> CD20<sup>+</sup> IgM<sup>++</sup>) and transitional (CD10<sup>−</sup> CD38<sup>++</sup> CD20<sup>+</sup> IgM<sup>++</sup>) as well as class switched memory ...
B cellGerminal centerIgDWe have identified and isolated a subpopulation of IgD+ B cells (IgD+CD38+ B cells) from human tonsils which expresses the germinal center (GC)-associated surface markers CD10, CD38, CD75, CD77 and Cd95/Fas. The heterogeneity of expression of several markers on IgD...
However, flow cytometry and immunohistochemistry phenotyping revealed that the cells were CD138−/CD38+/CD19+/CD4+/CD56−/CD117−. Conclusions PCL is diagnosed on peripheral blood smear. Immunophenotyping is a tool that can be helpful in diagnosing difficult cases but its atypical findings ...
B cellCD38IgDESSDAIIgGAutoantibodiesWe investigated the correlation between the increaIshioka-TakeiKeioErikoKeioYoshimotoKeioKeikoKeioSuzukiKeioKatsuyaKeioNishikawaKeioAyumiKeioYasuokaKeioHidekataKeioClinical immunology: The official journal of the Clinical Immunology Society...