Notably, the proportion of CD38+IgD+ was significantly and positively correlated with the serum IgG level among pSS patients (R2=0.5723). These results raise the possibility that increased serum IgG level in pSS patients was attributed to an increase in the population of this activated B cell ...
骨髓活检示:浆样细胞数量增加(约70%),Kappa阳性,Lambda阴性,CD20阴性,CD38和CD138阳性,考虑浆样细胞增生性肿瘤,不能排除浆样细胞白血病的可能,请结合临床及遗传学检查。 免疫组化:MPO、CD15粒系(+),E-cad红系(+),CD42b巨核系(+)、CD3(T细胞+)、CD20(个别...
We have identified and isolated a subpopulation of IgD+ B cells (IgD+CD38+ B cells) from human tonsils which expresses the germinal center (GC)-associated surface markers CD10, CD38, CD75, CD77 and Cd95/Fas. The heterogeneity of expression of several markers on IgD+ CD38+ B cells sugges...
a Flow panel of B cell subsets in the PBL (left) and in NP (right): naïve or IgD+ B cell: CD19+IgD+CD27−, CD27+ memory B cell (CD27+M): CD19+IgD−CD27+CD38−, and antibody secreting cells (ASC): CD19+IgD−CD27+CD38++. b Frequency of B cell subsets (Naïve...
抗免疫球蛋白D抗体(anti-immunoglobulin D antibody,抗IgD抗体)一直以来主要作为工具药来研究正常B细胞上的膜结合型IgD(membrane IgD,m IgD).最新研究表明,在病理状态下,抗IgD抗体可以通过选择性清除成熟B细胞,降低自身抗体的水平,抑制B细胞上B细胞活化因子(B cell activating factor belonging to the TNF family,BAF...
Plasmodium falciparum infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell s
B cellGerminal centerIgDWe have identified and isolated a subpopulation of IgD+ B cells (IgD+CD38+ B cells) from human tonsils which expresses the germinal center (GC)-associated surface markers CD10, CD38, CD75, CD77 and Cd95/Fas. The heterogeneity of expression of several markers on IgD...
Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individuals CD8+T cells are critical for effective host defenses against viral infections. Studies addressing HIV-induced immune responses in infected individuals have... TW...
However, flow cytometry and immunohistochemistry phenotyping revealed that the cells were CD138−/CD38+/CD19+/CD4+/CD56−/CD117−. Conclusions PCL is diagnosed on peripheral blood smear. Immunophenotyping is a tool that can be helpful in diagnosing difficult cases but its atypical findings ...
Absolute CD19<sup>+</sup> B cell counts, including counts of immature (CD10<sup>+</sup> CD38<sup>++</sup> CD20<sup>+</sup> IgM<sup>++</sup>) and transitional (CD10<sup>−</sup> CD38<sup>++</sup> CD20<sup>+</sup> IgM<sup>++</sup>) as well as class switched memory ...