Mini-review CD4 T cells are required for CD8 T cell memory generation. Eur J Immunol. v. 33, n. 12, p. 3225-3231, Dec 2003.Bourgeois C, Tanchot C (2003) Mini-review CD4 T cells are required for CD8 T cell memory generation. Eur J Immunol 33(12):3225–3231 View Article...
While the majority of cancer immunotherapies focus on harnessing the anti-tumour CD8 cytotoxic T cell response, the potential role of CD4 'helper' T cells has largely remained in the background. In this review, we give an overview of the multifaceted role of CD4 T cells in the anti-tumour...
During priming, help signals are relayed from CD4+ T cells to CD8+ T cells by specific dendritic cells to optimize the magnitude and quality of the CTL response. In this Review, we highlight the cellular dynamics and membrane receptors that mediate CD4+ T cell help and the molecular ...
cells secrete a full range of T cell cytokines and can be polarized to secrete particular restricted patterns of secretion for both CD4 and CD8 T cells... RW Dutton,LM Bradley,SL Swain - 《Annual Review of Immunology》 被引量: 1495发表: 1998年 CD4|[plus]| T cells are required for seco...
This review provides an overview of our current understanding of the roles of CD4 T cell subpopulations in atherosclerosis.doi:10.1016/S0753-3322(03)00082-9Xinghua ZhouBiomedicine & PharmacotherapyZhou X: CD4+ T cells in atherosclerosis . Biomed Pharmacother 2003, 57 :287–291....
During T-cell differentiation in the thymus, CD4+CD8+double-positive (DP) precursors must make a lineage decision to become CD4+(helper) or CD8+(cytotoxic) T cells. Two models have been proposed to explain how a T cell that expresses a TCR with an unpredictable specificity emerges from the...
A relatively new paradigm in αβCD4 T-cell biology indicates that T cells are much more flexible than previously appreciated, with the ability to change between helper phenotypes, between helper and follicular helper, or, most extremely, between helper and regulatory functions. In this review, ...
While the majority of cancer immunotherapies focus on harnessing the anti-tumour CD8 cytotoxic T cell response, the potential role of CD4 'helper' T cells has largely remained in the background. In this review, we give an overview of the multifaceted role of CD4 T cells in the anti-tumour...
Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–peptide complexes to control phagosomal infections, help B cells, regulate tissue homeostasis and repair or perform immune regulation. Memory CD4+ T cells are positioned throughout the body and not only protect...
CD4+T cells in infection clearance and autoimmune pathogenesis, suggesting the existence of a distinct innate-like immunological function performed by conventional T cells. In this review, we discuss the inflammatory mediators that activate bystander CD4+T cells and the potential physiological roles of ...