athe presence of CD4 T cells is required to achieve the full therapeutic efficacy of imatinib against Myc oncogene-addicted tumor cells 要求CD4 t淋巴细胞出现达到imatinib充分的治疗效力反对Myc对致癌基因上瘾的肿瘤细胞[translate]
stimulation14,15. Interestingly, the TCR-independent activation of CD4+T cells has primarily been observed in memory (CD44high) cells, while naïve (CD44low) cells exhibit lower reactivity13,14,15. Thus, it appears that cytokines and innate receptors, such as Toll-like receptors (TLRs), ca...
[CD4.sup.+] T cells sponsor oncogene addictsCD4 + T cells mediate the effects of oncogene inactivation on tumour growth and survival.. 2011 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.Kirsty Minton...
T cell-mediated responses have been implicated in the development of fibrosis, impaired lymphangiogenesis, and lymphatic dysfunction in secondary lymphedema. Here we show that CD4+ T cells are necessary for lymphedema pathogenesis by utilizing adopt
During this period, the cells proliferate but the TCR genes remain unrearranged. Once the cells stop expressing c-Kit and markedly reduce CD44 expression, they begin to rearrange their TCR genes. The earliest stages of T-cell lineage commitment...
Approaches that enhance radiation effect may lead to improved clinical outcome and decrease toxicity. Here we investigated whether activated CD4+ T cells (aCD4) can serve as an effective radiosensitizer. CD4+ T cells were activated with anti-CD3 and anti
The distribution of CD4+ T-cell counts was similar between the two databases: CD4+ T-cell count 1 with mean 334 cells/mm3 (SD 204 cells/mm3) in HIV-BCS versus 356 cells/mm3 (SD 216 cells/mm3) in SISCEL database. The proportion of detectable in the first count shows + 1.6% for ...
et al. HIV preferentially infects HIV-specific CD4+ T cells. Nature. 2002;417:95-9811986671Google ScholarCrossref 18. Hazenberg MD, Hamann D, Schuitemaker H, Miedema F. T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock. Nat Immunol. 2000;1:285-28911017098Google...
During chronic infection, effector CD4+T cells support the maintenance of functional CD8+T cells through secretion of IL-21, whereas TRegcells dampen the CD8+T cell response through suppression of DCs. Abstract Following infection, T cells differentiate into a heterogeneous population of effector T ...
However, the role of CD4 T cells in the hemagglutinin stalk-specific immune response is not clear. Here we identified a mouse CD4 T-cell epitope that encompasses residues HA2113-131 from the hemagglutinin stalk domain after a sub-lethal infection of influenza. In response to stimulation with ...