[3]Park H, Li Z, Yang X O,et al.A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol,2005,6(11): 1133-1141 [4]Fantini M C, Becker C, Monteleone G,et al.Cutting edge: TGF-beta ...
[3]Park H, Li Z, Yang X O,et al.A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol,2005,6(11): 1133-1141 [4]Fantini M C, Becker C, Monteleone G,et al.Cutting edge: TGF-beta ...
Osum KC, Jenkins MK. Toward a general model of CD4+ T cell subset specification and memory cell formation. Immunity. 2023;56(3):475-484. doi:10.1016/j.immuni.2023.02.010 Oh DY, Fong L. Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolbox. Immunity. 2021;54(12):27...
Osum KC, Jenkins MK. Toward a general model of CD4+ T cell subset specification and memory cell formation. Immunity. 2023;56(3):475-484. doi:10.1016/j.immuni.2023.02.010 Oh DY, Fong L. Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolbox. Immunity. 2021;54(12):27...
CD4+T细胞与IFN-γ调控巨细胞病毒在中枢神经系统神经元中的潜伏感染机制 《Journal of Neuroinflammation》:Neuron-restricted cytomegalovirus latency in the central nervous system regulated by CD4+ T-cells and IFN-γ 编辑推荐: 本期推荐:研究团队通过小鼠模型和人胎儿脑组织实验,揭示CD4+...
去除双细胞:使用DoubletFinder工具去除双细胞(doublets cells),这些是可能影响数据质量的异常细胞。 T细胞提取:基于CD3和CD4的表达,提取出T细胞,并使用Seurat进行下游再分析。 标准化和变量基因识别:对原始计数数据进行标准化,并使用Seurat中的NormalizeData和FindVariableFeatures函数识别变量基因。
Treg细胞在生理状态下主要通过抑制其他免疫细胞的活性,维持免疫平衡,防止过度免疫反应;而在肿瘤组织中,则表现出促进肿瘤生长的作用。CD4+ T细胞在肿瘤微环境中的作用十分多样,下面小编首先通过一篇今年发表在Nature cancer上,篇名为:CD4+ T cells in cancer的综述,来系统认识一下肿瘤组织中CD4+ T细胞的千人千面。
3.Śledzińska, A. et al. Regulatory T cells restrain interleukin-2- and Blimp-1-dependent acquisition of cytotoxic function by CD4+ T cells. Immunity 52, 151–166 (2020).4.Corthay, A. et al. Primary antitumor immune response mediated by CD4+ T cells. Immunity 22, 371–383 (2005)....
外周血中T细胞分化遵循线性途径,主要从幼稚CD4+T细胞开始逐渐分化。但是在胎儿肠道中主要为CD45RA-CCR7-CD4+ T cells. 这里给大家稍微介绍下这个标记分类:根据CD45RA和CCR7的表达,CD4+T细胞可分为Tnaive(CD45RA+CCR7+), Tcm(CD45RA-CCR7+)和Tem(CD45RA-CCR7-)三群。
这周的文献选自《Cell》名为“Stress-Induced Metabolic Disorder in Peripheral CD4+T Cells Leads to Anxiety-like Behavior”通过在小鼠中模拟应激的环境,进一步分析T细胞的变化,以及线粒体相关代谢途径发挥的作用。 身体或精神上的压力会导致大脑的神经可塑性,增加抑郁和焦虑的风险。压力暴露导致外周血T淋巴细胞功能...