Bilous M, Liu YC, Li X, Saillard M, Cenerenti M, Rockinger GA, Romero P,Jandus C. Tumor-specific cytolytic CD4 T cells mediate immunity against humancancer. Sci Adv. 2021 Feb 26;7(9):eabe3348
[3]Park H, Li Z, Yang X O, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol, 2005, 6(11): 1133-1141 [4]Fantini M C, Becker C, Monteleone G, et al. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25-...
[3]Park H, Li Z, Yang X O,et al.A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol,2005,6(11): 1133-1141 [4]Fantini M C, Becker C, Monteleone G,et al.Cutting edge: TGF-beta ...
Speiser DE, Chijioke O, Schaeuble K, Münz C. CD4+ T cells in cancer. Nat Cancer. 2023;4(3):317-329. doi:10.1038/s43018-023-00521-2 Guo M, Liu MYR, Brooks DG. Regulation and impact of tumor-specific CD4+ T cells in cancer and immunotherapy. Trends Immunol. Published online March ...
2024年7月24日,圣路易斯华盛顿大学医学院的研究人员在国际顶尖学术期刊Nature上发表了题为:Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy的研究论文。 该研究表明,具有维持外周耐受作用的细胞毒性1型调节性T细胞(Tr1细胞),也会...
Treg细胞在生理状态下主要通过抑制其他免疫细胞的活性,维持免疫平衡,防止过度免疫反应;而在肿瘤组织中,则表现出促进肿瘤生长的作用。CD4+ T细胞在肿瘤微环境中的作用十分多样,下面小编首先通过一篇今年发表在Nature cancer上,篇名为:CD4+ T cells in cancer的综述,来系统认识一下肿瘤组织中CD4+ T细胞的千人千面。
近日,这项研究的研究结果发表在《Nature Methods》上,题为“Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4 T cells allows complex functional analyses+”。 https://doi.org/10.1038/s41592-021-01328-8 “静息的CD4+ T细胞不会分裂分化,几乎不适合所有的基因...
3.Śledzińska, A. et al. Regulatory T cells restrain interleukin-2- and Blimp-1-dependent acquisition of cytotoxic function by CD4+ T cells. Immunity 52, 151–166 (2020).4.Corthay, A. et al. Primary antitumor immune response mediated by CD4+ T cells. Immunity 22, 371–383 (2005)....
外周血中T细胞分化遵循线性途径,主要从幼稚CD4+T细胞开始逐渐分化。但是在胎儿肠道中主要为CD45RA-CCR7-CD4+ T cells. 这里给大家稍微介绍下这个标记分类:根据CD45RA和CCR7的表达,CD4+T细胞可分为Tnaive(CD45RA+CCR7+), Tcm(CD45RA-CCR7+)和Tem(CD45RA-CCR7-)三群。
Naive CD4+T细胞:是一类尚未遇到抗原的 T 辅助细胞(T helper cells, Th)。它们在胸腺中发育成熟后进入外周免疫系统,处于静息状态,尚未被抗原刺激或激活。 辅助性T细胞:主要通过信号传导支持其他免疫细胞的功能。根据它们分泌的细胞因子不同,可以分为多个亚型(Th1,Th2,Th9,Th17,Th22,Tfh),每种亚型在免疫应答中发...