The discovery that functionally heterogeneous CD4+ T-cell subsets secrete different cytokines offers an explanation for the ability of certain T cells to mediate a predominant cell-mediated immune response versus a humoral response often accompanied by allergic manifestations. Th1 cells, important for ...
如今,在一项新的研究中,来自美国拉霍亚免疫学研究所(LJI)的研究人员在CD4+辅助性T细胞亚群中发现了与自身免疫性疾病风险有关的新基因。相关研究结果近期发表在Science Immunology期刊上,论文标题为“Single-cell eQTL analysis of activated T cell subsets reveal...
CD4+T-cell subsets in autoimmunity CD4+T-cell subsets in autoimmunity O'GARRA A. Curr. Opin. Immunol. 9, 872-883, 1997 O&apos,A Garra - 《Curr.opin.immunol》 被引量: 318发表: 1997年 CD4+ T-cell subsets in autoimmunity The discovery that functionally heterogeneous CD4+ T-cell subsets...
CD4 T-cell subsets in transplantation doi:10.1111/imr.12038Immunological ReviewsLiu, ZhongminFan, HuiminJiang, Shuiping
ObjectiveA subset of CD4+ T cells in the synovium of patients with rheumatoid arthritis (RA) produce CXCL13, a chemokine that is crucial for the formation of germinal centers. This study was undertaken to determine the relevance of this population to known subsets of T helper cells and to pr...
T helper type 1 (... Z Liang,MMW Chong,RL Dan - 《Immunity》 被引量: 2515发表: 2009年 Lineage relationship and protective immunity of memory CD8 T cell subsets. Memory CD8 T cells can be divided into two subsets, central (T[sub CM]) and effector (T[sub EM]), but their lineage ...
. They are MHC class II-restricted and are important mediators of adaptive immunity. These cells are involved in both the induction and the restraint of most immunological functions. A key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T cell....
Immunity to viruses is typically associated with the development of cytotoxic CD8+ T cells. However, CD4+ T cells are also important for protection during viral infection. Here, the authors describe the various ways in which different CD4+T cell subsets
et al. Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. Immunity 38, 187–197 (2013). Article CAS PubMed Google Scholar Ugur, M., Schulz, O., Menon, M. B., Krueger, A. & Pabst, O. Resident CD4+ T cells accumulate in lymphoid ...
The above results suggest that NG52 reduced the infiltration of cardiac CD4+ T subsets and other immune cells, and suppressed the expression of pro-inflammatory cytokines. 4. PGK1 regulates CD4 T cell maturation and Th17 responses in the periphery ...