Michael St Paul , Pamela S Ohashi.The Roles of CD8+ T Cell Subsets in Antitumor Immunity,Trends Cell Biol. 2020 Sep;30(9):695-704. doi: 10.1016/j.tcb.2020.06.003. Yuki Muroyama, E John Wherry.Memory T-Cell Heterogeneity and Terminology.Cold Spring Harb Perspect Biol. 2021 Oct 1;13(...
However, emerging evidence suggests distinct subsets of effector CD8 T cells that each exhibit unique effector functions and therapeutic potential. This review highlights recent advancements in our understanding of CD8 T-cell subsets and the contributions of these cells to various disease pathologies. ...
Mogues, T., Goodrich, M. E., Ryan, L., LaCourse, R. & North, R. J. The relative importance of T cell subsets in immunity and immunopathology of airborneMycobacterium tuberculosisinfection in mice.J. Exp. Med.19...
综述文献解析:CD8+ T细胞亚群在抗肿瘤免疫中的作用 (The Roles of CD8+ T Cell Subsets in Antitumor Immunity) 导读 本文是针对论文《CD8+ T细胞亚群在抗肿瘤免疫中的作用(The Roles of CD8+ T Cell Subsets …
本文是针对论文《CD8+ T细胞亚群在抗肿瘤免疫中的作用(The Roles of CD8+ T Cell Subsets in Antitumor Immunity)》的一篇解析,该论文于2020年7月发表于《细胞生物学的发展趋势(Trends in Cell Biology)》。 综述背景:相关研究表明CD8+T细胞在抗肿瘤治疗过程中起到至关重要的作用,与CD4+T细胞相似, CD8+T细胞也...
基于典型的记忆性特征和特殊组织定位，他们将其命名为肿瘤引流淋巴结抗原特异性记忆CD8+ T细胞，即TdLN-TTSM(Tumor Draining Lymph Node derived Tumor Specific Memory T cell)。随后通过高通量测序分析，研究人员发现在单细胞层面，TdLN-TTSM细胞转录特征更接近经典记忆细胞，而与耗竭T细胞差异较大。进一步分析ATAC-seq...
资料|CD8+ T细胞亚群介绍 关于CD4+辅助T细胞的亚型大家应该看得比较多,各种文章也介绍的非常详细,如下图所示: 但CD8效应T细胞的亚型分类确实很少听到,以致我一直以为效应CD8+细胞是一类产生IFN-γ和颗粒酶(诱导细胞凋亡) 的同质细胞毒性细胞群。 刚好前几天看到一篇文献(The Roles of CD8+T Cell Subsets in ...
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E. Effector-like CD8+ T cells in the memory population mediate potent protective. Immun. Immunity 38, 1250–1260 (2013). Article CAS Google Scholar Gerlach, C. et al. The chemokine receptor CX3CR1 defines three antigen-experienced CD8 T cell subsets with distinct roles in immune ...
Weninger, W., Manjunath, N. & von Andrian, U. H. Migration and differentiation of CD8+T cells.Immunol. Rev.186, 221–233 (2002). ArticleCASPubMedGoogle Scholar Wherry, E. J. et al. Lineage relationship and protective immunity of memory CD8 T cell subsets.Nature Immunol.4, 225–234 ...