导语:该研究深入探讨了具有干细胞样特性的CD4 T细胞如何控制对癌症的免疫反应,特别是在调节性T细胞(Treg)的抑制下,这些细胞如何影响肿瘤的进程和对免疫疗法的响应。 在2024年9月,Nature杂志发表了题为“Differentiation fate of a stem-like CD4 T...
[1]Chalmin F, Humblin E, Ghiringhelli F, et al. Transcriptional programs underlying Cd4 T cell differentiation and functions. Int Rev Cell Mol Biol, 2018, 341: 1-61 [2]Mosmann T R, Cherwinski H, Bond M W, et al. Two types of murine helper T cell clone. I. Definition according...
近期,STAR Protocols 期刊在线发表了“Characterizing CD4 T cell differentiation in mouse small intestine using T cell transfer, lamina propria preparation, and flow cytometry”的方法文章。 研究T细胞的基因功能对于理解生理和疾病发病机制是至关重要的。这里,作者提供了可用于粘膜免疫功能的研究的方案。文章亮点如...
To study the regulating mechanism and function of Th cells, in vitro CD4 T-cell differentiation is crucial. The following protocols describe the methods to induce nave CD4+ T-cell differentiate into Th1, Th2, Th17 and Treg by activating TCR, together with the different cytokines and blocking ...
CD4+ T helper 2 cells - microbial triggers, differentiation requirements and effector functions SummaryOver the past 10years we have made great strides in our understanding of T helper cell differentiation, expansion and effector functions. Within the... Isobel,S.,Okoye,... - 《Immunology》 被...
文章来源:Ruterbusch M, Pruner KB, Shehata L, Pepper M. In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm. Annu Rev Immunol(IF=28). 2020 Apr 26;38:705-725. doi: 10.1146/annurev-immunol-103019-085803. PMID: 32340571. ...
CD4+ T Cell Differentiation and Activation 来自 Semantic Scholar 喜欢 0 阅读量: 36 作者:Jim Reed,Scott A. Wetzel 摘要: The activation and differentiation of CD4+T cells play a critical role in establishing and subsequently controlling protective adaptive immune responses. Flow cytometry is a ...
Naive CD4+ T cells undergo massive proliferation and differentiation into at least four distinct helper T cell subsets after recognition of foreign antigen–derived peptides presented by dendritic cells. Each helper T cell subset expresses a distinct set
Christie D, Zhu J. Transcriptional regulatory networks for CD4 T cell differentiation. In: Ellmeier W, Taniuchi I (eds). Transcrip- tional Control of Lineage Differentiation of Immune Cells, Switzer- land: Springer, 2014;125-72.Christie D, Zhu J. Transcriptional regulatory networks for CD4...