[1]Chalmin F, Humblin E, Ghiringhelli F, et al. Transcriptional programs underlying Cd4 T cell differentiation and functions. Int Rev Cell Mol Biol, 2018, 341: 1-61 [2]Mosmann T R, Cherwinski H, Bond M W, et al. Two types of murine helper T cell clone. I. Definition according...
近期,STAR Protocols 期刊在线发表了“Characterizing CD4 T cell differentiation in mouse small intestine using T cell transfer, lamina propria preparation, and flow cytometry”的方法文章。 研究T细胞的基因功能对于理解生理和疾病发病机制是至关重要的。这里,作者提供了可用于粘膜免疫功能的研究的方案。文章亮点如...
[1]Chalmin F, Humblin E, Ghiringhelli F,et al.Transcriptional programs underlying Cd4 T cell differentiation and functions. Int Rev Cell Mol Biol,2018,341: 1-61 [2]Mosmann TR, Cherwinski H, Bond MW,et al.Two types of murine helper ...
导语:该研究深入探讨了具有干细胞样特性的CD4 T细胞如何控制对癌症的免疫反应,特别是在调节性T细胞(Treg)的抑制下,这些细胞如何影响肿瘤的进程和对免疫疗法的响应。 在2024年9月,Nature杂志发表了题为“Differentiation fate of a stem-like CD4 T...
文章来源:Ruterbusch M, Pruner KB, Shehata L, Pepper M. In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm. Annu Rev Immunol(IF=28). 2020 Apr 26;38:705-725. doi: 10.1146/annurev-immunol-103019-085803. PMID: 32340571. ...
[1] Takeuchi A , Saito T . CD4 CTL, a Cytotoxic Subset of CD4+ T Cells, Their Differentiation and Function[J]. Frontiers in Immunology, 2017, 8:194. [2] Juno J A , David V B , Kent S J , et al. Cytotoxic CD4 T Cells—Friend or Foe during Viral Infection?[J]. Frontiers in...
To study the regulating mechanism and function of Th cells, in vitro CD4 T-cell differentiation is crucial. The following protocols describe the methods to induce nave CD4+ T-cell differentiate into Th1, Th2, Th17 and Treg by activating TCR, together with the different cytokines and blocking ...
1. Taniuchi I: CD4 Helper and CD8 Cytotoxic T Cell Differentiation. Annu Rev Immunol 2018, 36:579-601. 2. Lio CWJQ, Hsieh CS: A two-step process for thymic regulatory T cell development. Immunity 2008, 28(1):100-111. 3. Andrews LP, Vignali KM, Szymczak-Workman AL, Burton AR, Br...
CD4细胞,也可以表示为CD4+T细胞,是T淋巴细胞的一种(T淋巴细胞可以根据其表面的某种特异蛋白质分子来划分为不同种类或亚群,不同亚群的T淋巴细胞就是根据这些特异蛋白质分子的名称而得名,这样,CD4细胞,就是表面有CD4分子的T淋巴细胞。另外,CD本身是cluster of differentiation的首字母缩写,可以解释为"分化簇、分化群...