Cancer immunology and immunotherapy are driving forces of research and development in oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent progress highlights the importance of CD4+ T cells, corresponding to the long-known fact that CD4+ T cells are central players and...
Cancer immunotherapy aims to promote the activity of cytotoxic T lymphocytes (CTLs) within a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish efficient and durable antitumour immunity. During priming, help signals are relayed from CD4+ T cells to CD8+ T cells...
CD4+ T cells can either enhance or inhibit tumour immunity. Although regulatory T cells have long been known to impede antitumour responses1–5, other CD4+ T cells have recently been implicated in inhibiting this response6,7. Yet, the nature and function
T cells in cancer Abstract Cancer immunology and immunotherapy are driving forces of research and development in oncology, mostly focusing on CD8+T cells and the tumor microenvironment. Recent progress highlights the importance of CD4+T cells, corresponding to the long-known fact that CD4+T cells ...
CD4~+ T Cells in Cancer Immunotherapy In recent years the realization that CD4+ T cells play a critical role in cancer immunotherapy has received growing attention. CD4+ T cells have been shown... RH Zeng,GZ Fang,L Wei - 《Chinese Journal of Cell Biology》 被引量: 34发表: 2008年 ...
Cancer ScienceWakabayashi O, Yamazaki K, Oizumi S et al (2003) CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests, are associated with favorable prognosis in human non-small cell can- cers. Cancer Sci 94(11):1003-1009...
antigen-specific cd4 + t cells regulate function of myeloid- derived suppressor cells in cancer via retrograde mhc class ii signaling Nagaraj S,Nelson A,Youn JI,et al.Antigen-Specific CD4+T Cells Regulate Function of Myeloid-Derived Suppressor Cells in Cancer via Retrograde MHC ClassⅡ... S ...
Despite the presence of Treg cells, endogenous stem-like CD4 T cells actively generated TH1 cells, which were required to restore TDLN effector CD8 T cell differentiation, enhance tumour control and rescue response to immunotherapy. In agreement, TH1 differentiation in patients with kidney cancer ...
Nagaraj, "CD4+ T cells suppress immune response to cancer: Novel targets for antitumor efforts," Expert Review of Clinical Immunology, vol. 8, no. 5... A Nelson,S Nair,S Nagaraj - 《Expert Rev Clin Immunol》 被引量: 3发表: 2012年 ...
& Munz, C. CD4+ T cells in cancer. Nat. Cancer 4, 317–329 (2023). Gutierrez-Melo, N. & Baumjohann, D. T follicular helper cells in cancer. Trends Cancer 9, 309–325 (2023). Oja, A. E., van Lier, R. A. W. & Hombrink, P. Two sides of the same coin: protective ...