Induction of anergic or regulatory tumor-specific CD4(+) T cells in the tumor-draining lymph node. Nat Commun, 9(1), 0. doi:10.1038/s41467-018-04524-x 8. Atsushi, Tanaka., Shimon, Sakaguchi.(2016). Regulatory T cells in cancer ...
CD4+T能够分泌IL2,激活NK和CD8+T淋巴细胞;也能够分泌IFNγ和TNF,激活巨噬细胞,从而维持了对肿瘤细胞的攻击。 在肿瘤组织附近的淋巴结组织中,CD4+T能够通过识别肿瘤抗原和共刺激信号,帮助筛选肿瘤特异性CD8+T细胞。 CD4+T本身能够通过TCR/CD4识别肿瘤抗原,一方面直接...
Cancer immunology and immunotherapy are driving forces of research and development in oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent progress highlights the importance of CD4+ T cells, corresponding to the long-known fac
CD4+ T cell help in cancer immunology and immunotherapy. Nat Rev Immunol. 2018;18(10):635-647. doi:10.1038/s41577-018-0044-0Speiser DE, Chijioke O, Schaeuble K, Münz C. CD4+ T cells in cancer. Nat Cancer. 2023;4(3):317-329. doi:10.1038/s43018-023-00521-2Guo M, Liu MYR, ...
DavidY Oh, Lawrence Fong, Evan W Newell, Mary Jo Turk, et al. Toward a betterunderstanding of T cells in cancer. Cancer Cell. 2021 Dec 13;39(12):1549-1552.CachotA, Bilous M, Liu YC, Li X, Saillard M, Cenerenti M, Rockinger GA, Romero P,Jandus C. Tumor-specific cytolytic CD...
(Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolbox)》的解析,该综述于2021年12月发表于Immunity(IF:43.474)。 综述背景: T细胞是免疫系统对抗癌症的重要效应器,分为CD8+T细胞和CD4+T细胞。通常只有CD8+T细胞被认为具有消灭肿瘤的作用,但临床研究已发现肿瘤中的CD4+T细胞也具有细胞毒性。
Cancer immunology and immunotherapy are driving forces of research and development in oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent progress highlights the importance of CD4+ T cells, corresponding to the long-known fac
We discuss regulatory mechanisms driving ontogeny and effector function and evidence for the clinical relevance of cytotoxic CD4 + Tcells in cancer. In this context, we highlight important gaps in understanding in the biology of cytotoxic CD4 + Tcells as well as the potential use of these cells...
Cancer immunotherapy aims to promote the activity of cytotoxic T lymphocytes (CTLs) within a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish efficient and durable antitumour immunity. During priming, help signals are relayed from CD4+ T cells to CD8+ T cells...
(Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolbox)》的解析,该综述于2021年12月发表于Immunity(IF:43.474)。 综述背景: T细胞是免疫系统对抗癌症的重要效应器,分为CD8+T细胞和CD4+T细胞。通常只有CD8+T细胞被认为具有消灭肿瘤的作用,但临床研究已发现肿瘤中的CD4+T细胞也具有细胞毒性。