Presence of T-cell receptor mRNA in functionally distinct T cells and elevation during intrathymic differentiation Understanding the differentiation of functionally distinct subsets of T lymphocytes is essential to unravel their crucial role in the immune response and a... Y Yoshikai,Y Yanagi,N Suciu-...
There was a corresponding decrease in the percentage of Thy 1.2+, CD4+, and CD8+ cells. No increase in cycling of B220+ cells was observed, suggesting an influx of B220+ cells into the node rather than proliferation. Elevation in 3H-TdR incorporation occurred as early as 4 h after anti...
Natural killer (NK) cells express surface receptors for defined groups of HLA class I alleles. The specific interaction between these receptors and HLA cla... MM Cristina,V Chiara,C Anna,... - 《International Immunology》 被引量: 585发表: 1995年 Induction of members of the IL-8/NAP-1 ge...
Cross-linking by plastic-bound goat anti-mouse antibodies (panning) failed to activate T cells, even in the presence of recombinant IL-1 or IL-2. In contrast, crosslinking of the anti-CD3 antibody Leu4 or Leu4 fragments was mitogenic in monocyte-free cultures. Measurements of intracellular ...
Here, we evaluated the ability of ISB 1342 to kill MM cells, which model some resistance mechanisms to daratumumab in patients. We demonstrate that ISB 1342 can successfully induce the killing of MM cell lines in vitro and in vivo, as well as primary MM cells in bone marrow aspirates (BMA...
Talquetamab is the first approved, off-the-shelf, T-cell-redirecting bispecific antibody that targets both the novel myeloma antigen G protein-coupled receptor family C group 5 member D (GPRC5D) and the CD3 receptor on T cells, inducing T-cell-mediated lysis of GPRC5D-expressing multiple mye...
Crosslinking HLA-DR molecules by monoclonal antibodies (mAb) induces protein tyrosine phosphorylation and results in a secondary elevation of free cytoplasmic Ca 2+ concentration ([Ca 2+ ] i ) in activated human T cells. Here we have studied the effect of DR on CD3-induced signal transduction...
G19-4 (20 mg/ml) induced [Ca2/]i elevation in negatively selected T cells treated overnight with 10 mg/ml DGLA (solid line) or with medium alone (dashed line). Cells were left to run for 45- 50 sec to establish a basal fluorescence ratio [proportional to resting [Ca2/]i levels] ...
Upon engagement of TCR with peptide-MHC complexes displayed on the surface of antigen-presenting cells, T lymphocytes undergo a sustained elevation of intracellular Ca2+ concentration([Ca2+]i), which is required for cytokine production. In the present work, we investigate how inositol lipid ...
12It has been shown that DCs in mesenteric LNs (MLNs) induce T-cell expression of α4β7 receptors and CCR9 that mediate T-cell migration to gut tissues,13,14 because DCs in MLNs are able to metabolize vitamin A into retinoic acid (RA) that induces T cells to up-regulate α4β7 ...