综上所述,本研究强调了CD38在维持T-LGLs和T-ALL细胞稳态中的关键调控角色,巩固了其作为这两种疾病治疗中极具潜力的治疗靶点的地位。 参考资料:Ruonan Li, Ke Huang, Lele Zhang, Chen Qiu, LinZhu Tian, YaJing Chu, WeiPing Yuan, ...
(E) 使用 VPD 标记 MOLM-13 细胞,分别用 isatuximab 和 CD38-TCE 及其相应同型对照进行 30 分钟预处理,然后与健康成人 PBMC(n = 6)以 10:1 E:T 比共培养 48 小时。效应细胞的激活通过 CD69+ T 和 NK 淋巴细胞的百分比...
在T细胞中,CD38与CD31或单克隆抗体结合后可诱导白细胞介素(Interleukin, IL)-6、IL-10 、干扰素(interferon, IFN)-γ、粒细胞-巨噬细胞集落刺激因子的表达,与T细胞受体(T cell receptor, TCR)/CD3激活诱导的mRNA分子类型有显著重叠。CD38结合后TCR/CD3复合体发生了快速和特异性调节,这为CD38与T、B和NK细胞中T...
CD38在多数肿瘤中高表达,在非实体瘤中,如慢性淋性白血病CLL、Waldenström’s macroglobulinemia、primary systemic amyloidosis、套细胞淋巴瘤MCL、急性髓系白血病AML、急性淋系白血病ALL、NKcell leukemia、NK/T-cell lymphoma (NKTCL)等肿瘤细胞中均有较高的表达,但CD38表达最高的当属多发性骨髓瘤(multiple myeloma,...
B cell differentiationCD38Oreochromis niloticusT cell-dependent responseCD38 is a multifunctional cell surface molecule that plays a crucial role in B cell activation, differentiation, and maturation in mammals with an increased expression in B cell maturation. In this study, a CD38-like molecule (On...
2024年2月2日,浙江大学医学院附属第一医院黄河教授与浙江大学基础医学院钱鹏旭研究员及浙江大学医学院附属第一医院胡永仙主任医师团队合作,在Cell Reports Medicine期刊发表了题为:Inhibition of CD38 enzymatic activity enhances CAR-T cell immune-therapeutic efficacy by repressing glycolytic metabolism 的研究论文。
Nature Reviews Molecular Cell Biology(2024) Novel insight into nicotinamide adenine dinucleotide and related metabolites in cancer patients undergoing surgery Hiroaki Fujita Taiichi Wakiya Kenichi Hakamada Scientific Reports(2024) CD38 in SLE CD4 T cells promotes Ca2+ flux and suppresses interleukin-2 produ...
近年来,CAR-T细胞疗法成为了血液系统恶性肿瘤及自身免疫疾病最具前景的治疗手段之一,CD38被确定为耗竭CAR-T细胞的潜在标志,抑制CD38酶活性可增强CAR-T细胞的细胞毒性和抗肿瘤功效,抑制CD38可逆转衰竭并改善CAR-T细胞功能,从机制上讲,CD38抑制通过特定的信号通路抑制糖酵解,表明CD38抑制在增强CAR-T细胞治疗方面的潜在临床...
We have previously reported that a peripheral blood absolute CD38brightCD8+ effector memory T cell (TEM) population expansion of >35 cells/µL predicts the development of acute graft-versus-host disease (GVHD). We hypothesized that these T cells are activated, proliferating, and cytotoxic traffic...
In this study we present data supporting that most CD38 is pre-assembled in a subset of Brij 98-resistant raft vesicles, which were stable at 37 degrees C, and have relatively high levels of Lck and the CD3-zeta subunit of T cell antigen receptor-CD3 complex in contrast with a Brij 98...