这两项研究都表明,在NSG-BLT小鼠体内表达MART-1-TCR的CD8+T细胞可以控制移植的HLA-A2+黑色素瘤的生长【Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice】。NSG-BLT小鼠也被用来证明体外激活的人NK细胞对低分化的人口腔鳞癌干细胞的抗肿瘤活性。另一项研究表明,人脐血...
Suppression of Active HIV-1 Infection in CD34+ Hematopoietic Humanized NSG Mice by a Combination of Combined Antiretroviral Therapy and CCR5 Targeting Drugs.HIV-1HIV-1 preventionantiretroviral therapyHIV-1 persistenceSignificant progress has been made in the diagnostics and treatment of AIDS since the ...
cells into sublethally irradiated NSG mice did not lead to leukemia development (Supplementary Figure S7), thereby arguing either for the necessity of additional hits or the absence of specialized bone marrow niches for full blast cell transformation of human hematopoietic progenitors in NSG mice. ...
A Novel in-Vivo Model of Human Myelofibrosis Based on Transplantation of Thrombopoietin Overexpressing CD34+ Cells into Humanized Bone Marrows in NSG Mice ... H Li,A Sierras,A Hultquist,... - 《Blood》 被引量: 0发表: 2024年 Adenovector-Mediated Expression of Human Thrombopoietin cDNA in Im...
Leukemia-initiating cell activity of IL-3Rα–positive FA-AML cells in a “humanized” xenotransplant model To establish the LSC functional capacity of IL-3Rα–positive FA-AML cells, we performed transplantation studies using the NSG/SGM3 xenotransplantation model. These recipient mice express tra...
we observed an increased number of human hematopoietic cells in the bone marrow of mice receiving augmented PS-UCBCD34+cells in comparison with mice receiving non-augmented PS-UCBCD34+cells (8.81 ± 1.05% of hCD45+ cells vs 4.45 ± 1.12%, Fig.3c. For gating strategy see Supplem...
Humanized mice have become useful animal models for HIV/AIDS. Since NOD.Cg-Prkdc scid Il2rgtm1Wjl/SzJ (NSG) mice allow the engraftment of primary human immune cells, we aim to determine the role of human Fms-related tyrosine kinase 3 ligand (hFlt3L), a major growth factor for dendritic ...
Host deficiency in MHC class I, as occurs in beta-2 microglobulin knockout in either NOG or NSG mice, results in resistance to xGVHD, which permits a longer therapeutic window. In this article, detailed processes for generating humanized mice by transplantation of HSCs from cord blood-derived ...
Humanized NSG miceCD34 + human CB cellsIntrahepatic injectionHuman T cell developmentIn this study, we explore the possibility of human T cell development in the liver of humanized mice generated by intrahepatic injection of CD34 + hCB cells into conditioned NOD/SCID/IL-2R纬 null(NSG) newborn ...
fully reconstitute lympho-myeloid hematopoiesis in recipient mice. In contrast, the purification and isolation of bona fide human CD34−HSCs has lagged far behind the abovementioned murine CD34low/−KSL cells11. However, a number of studies have suggested that human bone marrow (BM)-derived ...